Chemistry: analytical and immunological testing – Optical result – Spectrum analysis
Reexamination Certificate
2001-08-03
2011-12-06
Alexander, Lyle (Department: 1773)
Chemistry: analytical and immunological testing
Optical result
Spectrum analysis
C436S518000, C436S525000, C422S082050, C422S082110, C356S301000, C356S246000
Reexamination Certificate
active
08071391
ABSTRACT:
This invention seeks to provide methods and apparatus for analysis. Electromagnetic radiation is transmitted through a plurality of metallic islands on a transparent substrate. A resultant optical property of the plurality of metallic islands is measured. Thereafter a chemical substance is adsorbed onto the plurality of metallic islands so as to produce a chemical substance-metallic islands moiety.Electromagnetic radiation is transmitted through the chemical substance-metallic islands moiety and a resultant optical property of metallic islands in the chemical substance-metallic islands moiety is measured. The resultant optical property of the metallic islands in chemical substance-metallic islands moiety and the resultant optical property of the plurality of metallic islands are employed so as to provide at least one of a quantitative indication and a qualitative indication of at least one of: the chemical substance-metallic islands moiety, a functionality of the chemical substance-metallic islands moiety, the plurality of metallic islands, a functionality of the plurality of metallic islands, the chemical substance and a functionality of the chemical substance.
REFERENCES:
patent: 4720633 (1988-01-01), Nelson
patent: 4764343 (1988-08-01), Nyberg
patent: 4802761 (1989-02-01), Bowen et al.
patent: 4880976 (1989-11-01), Mancuso et al.
patent: 5412211 (1995-05-01), Knowles
patent: 5449918 (1995-09-01), Krull et al.
patent: 5611998 (1997-03-01), Aussenegg et al.
patent: 5670978 (1997-09-01), Kobayashi et al.
patent: 5715334 (1998-02-01), Peters
patent: 5789748 (1998-08-01), Liu et al.
patent: 5792667 (1998-08-01), Florin et al.
patent: 5858799 (1999-01-01), Yee et al.
patent: 5866433 (1999-02-01), Schalkhammer et al.
patent: 5999315 (1999-12-01), Fukano et al.
patent: 6168825 (2001-01-01), O'Brien et al.
patent: 6184610 (2001-02-01), Shibata et al.
patent: 6208422 (2001-03-01), Naya
patent: 6221426 (2001-04-01), Yamanobe
patent: 6459482 (2002-10-01), Singh et al.
patent: 6623977 (2003-09-01), Farquharson et al.
patent: 6728429 (2004-04-01), Melman et al.
patent: 0 846 946 (1998-06-01), None
patent: 2000356587 (2000-12-01), None
patent: 98/09153 (1998-03-01), None
Aussenegg F.R. et al: “The metal island coated swelling polymer over mirror systems (MICSPONS): a new principle for measuring ionic strength.” Sensors and Acruators B 29(1995) pp. 204-209.
Schalkhammer Th. et al: “Detection of fluorophore-labelled antibodies by surface-enhanced fluroecence on metal nanoislands.” SPIE vol. 2976, pp. 129-136 (1997).
Schalkhammer Th..et al: “The use of metal-island-coated pH-sensitive swelling polymers for biosensor applications.” “Sensors and Actuators” B 24-25 (1995) pp. 166-172.
Palkovits R. et al: “Structural behavior of nanometric carbohydrate films transduced by a resonant technique.” Biopolymres, vol. 69 pp. 333-342 (2003).
Mayer Ch. et al: “Surface enhanced resonance of metal nano clusters: a novel tool for Proteomics.” Journal of Nanoparticle Research 3: pp. 361-371 (Dec. 2001).
Supplemental European Search Report, dated Mar. 10, 2009, from corresponding European Application No. EP 01 95 8330.
Kalyuzhny, G. et al., “Spectroscopic Characterization of self-Assembled Macrocycle Monolayers on Gold”, I. Rev. Anal. Chem. 1999, 18, pp. 237-242.
Kalyuzhny, G. et al., “UV/Vis Spectroscopy of Metalloporphyrin and Metallophthalocynanine Monolayers Self-Assembled on Ultrathin Gold Films”, I. 2000, J. Phys. Chem. B 104, pp. 8238-8244.
www.cranfield.ac.uk/biotech/spr.htm, 2001.
Charles A. Goss, et al., “Application of (3-Mercaptopropyl) Trimethoxysilane as a Molecular Adhesive in the Fabrication of Vapor-Deposited Gold Electrodes on Glass Substrates”, M. Anal. Chem. 1991, 63, pp. 85-88.
Kalyuzhny, G. et al., “Differential Plasmon Spectroscopy as a Tool for Monitoring Molecular Binding to Ultrathin Gold Films”, J. Am. Chem. Soc. 2001, 123, pp. 3177-3178.
Kalyuzhny Gregory
Rubinstein Israel
Vaskevich Alexander
Alexander Lyle
Houston Eliseeva LLP
Yeda Research and Development Company Ltd.
LandOfFree
Method and apparatus for detecting and quantifying a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for detecting and quantifying a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for detecting and quantifying a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4299381