Chemistry: analytical and immunological testing – Including sample preparation
Reexamination Certificate
2007-11-13
2007-11-13
Alexander, Lyle A. (Department: 1743)
Chemistry: analytical and immunological testing
Including sample preparation
C436S173000, C436S063000, C436S155000, C436S178000, C250S287000
Reexamination Certificate
active
10700297
ABSTRACT:
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
REFERENCES:
patent: 3896661 (1975-07-01), Parkhurst et al.
patent: 4022876 (1977-05-01), Anbar
patent: 4295046 (1981-10-01), Gruter et al.
patent: 4296332 (1981-10-01), Hill
patent: 4454233 (1984-06-01), Wang
patent: 4468468 (1984-08-01), Benninghoven et al.
patent: 4665192 (1987-05-01), Cerami
patent: 4686366 (1987-08-01), Stuke
patent: 4694167 (1987-09-01), Payne et al.
patent: 4705616 (1987-11-01), Andresen et al.
patent: 4902627 (1990-02-01), Kidwell
patent: 4988879 (1991-01-01), Zare et al.
patent: 5003059 (1991-03-01), Brennan
patent: 5045694 (1991-09-01), Beavis et al.
patent: 5073713 (1991-12-01), Smith et al.
patent: 5078135 (1992-01-01), Caprioli et al.
patent: 5118937 (1992-06-01), Hillenkamp et al.
patent: 5124267 (1992-06-01), Humpel et al.
patent: 5171989 (1992-12-01), Williams et al.
patent: 5209919 (1993-05-01), Turteltaub et al.
patent: 5260571 (1993-11-01), Cottrell et al.
patent: 5317932 (1994-06-01), Westlake, III et al.
patent: 5547835 (1996-08-01), Koster
patent: 5605798 (1997-02-01), Koster
patent: 5622824 (1997-04-01), Koster
patent: 5719060 (1998-02-01), Hutchens et al.
patent: 5894063 (1999-04-01), Hutchens et al.
patent: 6020208 (2000-02-01), Hutchens et al.
patent: 6027942 (2000-02-01), Hutchens et al.
patent: 6124137 (2000-09-01), Hutchens et al.
patent: 6225047 (2001-05-01), Hutchens et al.
patent: 6579719 (2003-06-01), Hutchens et al.
patent: 6897072 (2005-05-01), Rich et al.
patent: 3221681 (1983-12-01), None
patent: 0 084 086 (1983-07-01), None
patent: 0 333 912 (1989-09-01), None
patent: 2235528 (1991-03-01), None
patent: 2235529 (1991-03-01), None
patent: 2236184 (1991-03-01), None
patent: 2236185 (1994-03-01), None
patent: WO91/02961 (1991-03-01), None
patent: WO92/13629 (1992-08-01), None
patent: WO96/37777 (1996-11-01), None
patent: WO96/40888 (1996-12-01), None
patent: WO99/06833 (1999-02-01), None
American Biotechnology Laboratory, Feb. 1994 cover, cover-page 2 (1994).
Beavis, R. et al., “Epitaxial protein inclusion in sinapic acid crystals” J. Phys. D: Appl. Phys.26:442-447 (1993).
Dwyer, J. et al., “A novel sample preparation device for MALDI-MS” Intn'l Lab. 13A-13F (1997).
Hillenkamp, F., “Laser desorption mass spectrometry: Mechanisms techniques and applications” Bordeaux Mass Spect. Conference Report 11A:354-362 (1988).
Hutchens, T. et al., “Differences in the confrontational state of a zinc-finger DNA-binding protein domain occupied by zinc and copper revealed by electrospray ionization mass spectrometry” Rapid Comm. in Mass Spect. 6:469-473 (1992).
Hutchens, T. et al., “New desorption strategies for the mass spectrometric analysis of macromolecules” Rapid Comm. in Mass Spect. 7:576-580 (1993).
Karas, M. et al., “Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons” Anal. Chem. 60:2299-2301 (1988).
Karas, M. et al., “Ultraviolet laser desorption of proteins up to 120,000 daltons” Bordeaux Mass Spect. Conference Report 11A:416-417 (1988).
Karas, M. et al., “UV laser desorption/ionization mass spectrometry of femtomol amounts of large proteins” Biomed. Environ. Mass Spectr. 18:841-843 (1989).
Mock, K. et al., “Sample Immobilization protocols for matrix-assisted laser desorption mass spectrometry” Rapid Comm. in Mass Spec. 6:233-238 (1994).
Nelson et al., “Mass spec. analysis of a trans-metal-binding peptide using MALDTOFMS: A demonstration of probe tip chemistry” Rapid Comm. Mass Spec. 6:4-8 (1992).
Nelson et al., “Mass spectrometric immunoassay” Anal. Chem. 67:1153-58 (1995).
Rivera, A., “A summary statement: Probes for affinity mass spectrometry of phophoproteins” Apr. 16, 1994.
Speir, J. et al., “Substrater-assisted laser desorption of neutral peptide molecules” Anal. Chem. 64:1041-1045 (1992).
Strupat, K. et al., “2,5-Dihydroxybenzoic acid: A new matrix for laser desorption-ionization mass spectrometry” Int'l J. Mass Spectr. and Ion Proc. 111:89-102 (1991).
Xiang, F. et al., “A method to increase contaminant tolerance in protein matrix-assisted laser desorption/ionization by the fabrication of thin protein-doped polycrystalline films” Rapid Comm. in Mass Spec. 8:199-204 (1994).
Yip, T. et al., Protein Expression and Purification 2:355-362 (1991).
Brockman, A. et al., “Probe-immobilized affinity chromatography/mass spectrometry” Anal. Chem. 67(24):4851-5 (1995) [Abstract].
Brodbelt et al., “In vivo mass spectrometric determination of organic compounds in blood with a membrane probe” Anal. Chem. 59:454-458 (1987).
Fitzgerald, M. et al., “Direct characterization of solid phase resin-bound molecules by mass spectrometry” Bioorg. Med. Chem. Lett. 6(8):979-982 (1996) [Abstract].
Jonsson, G., et al., “Plasma desorption mass spectrometry of peptides and proteins adsorbed on nitrocellulose” Anal. Chem. 58(6):1084-1087 (1986).
Siuzdak, G. et al., “Applications of mass spectrometry in combinatorial chemistry” Biotech. Bioeng. 61(2):127-134 (1998) [Abstract].
Van Breemen et al., “Time-resolved laser desorption mass spectrometry. I. Desorption of performed ions” Interntnl. J. Mass Spectro. Ion Phys. 49: 36-51 (1983).
Tang et al., “Matrix-assisted laser desorption/ionization mass spectrometry of immobilized duplex DNA probes,”Nucleic Acids Research,23(16):3126-3131 (1995).
Cornish et al., “Laser Desorption Tandem Time-of-Flight Mass Spectrometry for Fragmentation Analysis of Biomolecules,” Abstract, Accession No. 4591121, Apr. 1993.
Hutchens T. William
Yip Tai-Tung
Alexander Lyle A.
Baylor College of Medicine
Townsend and Townsend / and Crew LLP
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