Chemistry: analytical and immunological testing – Biological cellular material tested
Reexamination Certificate
2006-07-11
2006-07-11
Alexander, Lyle A. (Department: 1743)
Chemistry: analytical and immunological testing
Biological cellular material tested
C436S155000, C436S173000, C436S174000, C436S178000, C250S287000, C250S288000
Reexamination Certificate
active
07074619
ABSTRACT:
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
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Hutchens T. William
Yip Tai-Tung
Alexander Lyle A.
Baylor College of Medicine
Townsend & Townsend & Crew LLP
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