Radiant energy – Ionic separation or analysis – Ion beam pulsing means with detector synchronizing means
Reexamination Certificate
2006-02-28
2006-02-28
Berman, Jack I. (Department: 2881)
Radiant energy
Ionic separation or analysis
Ion beam pulsing means with detector synchronizing means
Reexamination Certificate
active
07005633
ABSTRACT:
Disclosed are an apparatus and a method for separating ions produced at an electrospray ionization source, based upon the high field mobility properties of the ions. An apparatus according to the instant invention includes a high field asymmetric waveform ion mobility spectrometer (FAIMS) having an analyzer region defined by a space between an inner electrode (32) and an outer electrode (34). In particular, the outer electrode includes an ion inlet (38) for introducing ions into a first portion of analyzer region and an ion outlet (56) for extracting ions from a second portion of the analyzer region. The FAIMS is characterized in that a gas-directing conduit (48) is provided through at least a portion of the inner electrode. In particular, the gas-directing conduit includes an opening at a first end thereof for supporting fluid communication between the gas-directing conduit and the first portion of the analyzer region. The gas-directing conduit is adapted at a second end thereof opposite the first end for supporting fluid communication between a gas source and the gas-directing conduit. The opening is orientated relative to the ion inlet such that gas provided through the gas-directing conduit flows partially outwardly from the analyzer region through the ion inlet, so as to desolvate the ions produced at an ionization source (42, 45) as they are introduced into the analyzer region.
REFERENCES:
patent: 5420424 (1995-05-01), Carnahan et al.
patent: 5723861 (1998-03-01), Carnahan et al.
patent: 5736739 (1998-04-01), Uber et al.
patent: 6495823 (2002-12-01), Miller et al.
patent: 6504149 (2003-01-01), Guevremont et al.
patent: 6512224 (2003-01-01), Miller et al.
patent: 6621077 (2003-09-01), Guevremont et al.
patent: 6690004 (2004-02-01), Miller et al.
patent: 6753522 (2004-06-01), Guevremont et al.
patent: 2003/0038235 (2003-02-01), Guevremont et al.
patent: 2003/0089847 (2003-05-01), Guevremont et al.
patent: 2003/0132380 (2003-07-01), Miller et al.
patent: 2003/0150985 (2003-08-01), Guevremont et al.
patent: 2003/0213899 (2003-11-01), Guevremont
patent: WO 00/63949 (2000-10-01), None
patent: WO 01 69216 (2001-09-01), None
patent: WO 01 69217 (2001-09-01), None
patent: WO 01 69221 (2001-09-01), None
patent: WO 03/067236 (2003-08-01), None
patent: WO 2004/030129 (2004-04-01), None
Buryakov et al., “A New Method of Separation of Multi-Atomic Ions by Mobility at Atmospheric Pressure using a High-Frequency Amplitude-Asymmetric Strong Electric Field”, Int. J. Mass Spectrom. Ion Processes, No. 128, pp. 143-148, (1993), Elsevier Science Publishers B.V.
Eiceman et al., “Ion Mobility Spectrometry”, (1994), CRC Press, Florida.
Carnahan et al., “Field Ion Spectrometry—A New Analytical Technology for Trace Gas Analysis”, Proceedings of the 41st Annual ISA Analysis Division Symposium, paper #96-009, pp. 87-95, (1996), Framingham, MA, USA.
Purves et al., “Mass Spectrometric Characterization of a High-Field Asymmetric Waveform Ion Mobility Spectrometer”, Review of Scientific Instruments, vol.69, No. 12, pp. 4094-4105, (Dec. 1998), American Institute of Physics.
Henderson et al., “ESI/Ion Trap/Ion Mobility/Time-of-Flight Mass Spectrometry for Rapid and Sensitive Analysis of Biomolecular Mixtures”, Anal. Chem. 1999, vol. 71, No. 2, pp. 291-301, (Jan. 15, 1999), American Chemical Society.
Guevremont et al., “Atomspheric Pressure Ion Focusing in a High-Field Asymmetric Waveform Ion Mobility Spectrometer”, Review of Scientific Instruments, vol. 70, No. 2, pp. 1370-1\383, (Feb. 1999), American Institute of Physics.
Barnett David
Guevremont Roger
Purves Randy
Berman Jack I.
Freedman & Associates
Ionalytics Corporation
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