Optics: measuring and testing – Blood analysis – Hemoglobin concentration
Patent
1976-03-19
1978-01-03
Henry, Jon W.
Optics: measuring and testing
Blood analysis
Hemoglobin concentration
356244, 356205, G01N 3316, G01N 2116, G01N 2122
Patent
active
040663612
ABSTRACT:
An apparatus and method for deriving an oxygen association curve for a blood sample wherein the sample is placed on a transparent support and is covered by a gas-permeable membrane element. The support is mounted in a gas treatment chamber with transparent windows on opposite sides of the support to provide an optical path through the support normal to the sample. Radiant energy is directed along this optical path, said radiant energy including two light frequencies, one having a wavelength at which there is substantially no change in absorbance as between oxygenated and deoxygenated blood and the other having a wavelength at which there is a relatively large change in absorbance as between oxygenated and deoxygenated blood. A controlled source of deoxygenating gas, such as nitrogen, and a controlled source of oxygen are connected to the chamber. An oxygen electrode is mounted in the chamber and generates the X component, corresponding to oxygen in the chamber, in an X-Y recorder. The difference in absorption of the two frequencies is measured and from this is derived a signal forming the Y component in the X-Y recorder, which thus provides a curve corresponding to the light absorbance changes in the sample while it is being oxygenated.
REFERENCES:
"A Gas-Hemogloben Diffusion Photometer," F. Kreuzer and L. Garceau, IRE Trans. on Medical Electronics, July, 1960, pp. 207-210.
"On the Accuracy of an Improved Method for the Measurement of O.sub.2 -Dissociation Curves . . . ," Banirdl et al., Physiology of Oxygen Transport to Tissue, Nov. 1973, pp. 325-331.
"Studies on the Function of Abnormal Hemoglobins . . . ," Kiyohiro Imai et al., Biochimica et Biophysica Acta 200, (1970), pp. 189-196.
"A New Method for the Rapid Determination of Oxygen Dissociation Curves . . . ," L. A. Kiesow et al., Clinica Chimica Acta 41, (1972), pp. 123-129.
Baxter Travenol Laboratories Inc.
Collins Henry W.
Flattery Paul C.
Henry Jon W.
Kinney Richard G.
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