Method and apparatus for controlling the ion population in a...

Radiant energy – Ionic separation or analysis – Methods

Reexamination Certificate

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C250S288000

Reexamination Certificate

active

11077105

ABSTRACT:
A method of controlling the population of ions in a mass spectrometer in which a first sample of ions is provided in the mass spectrometer, a measure of abundance of a species of interest in the first sample of ions is determined, the measure of abundance comprising an intensity value, and a second sample of ions is introduced into the mass spectrometer. The second sample of ions is introduced in an amount determined at least in part on the measure of abundance of the species of interest in the first sample of ions.

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patent: 5448061 (1995-09-01), Wells
patent: 5479012 (1995-12-01), Wells
patent: 5572022 (1996-11-01), Schwartz et al.
patent: 6555814 (2003-04-01), Baykut et al.
patent: 6958473 (2005-10-01), Belov et al.
patent: 2004/0200959 (2004-10-01), Kovtoun
patent: 0 905 743 (1999-03-01), None
patent: WO 2004/068532 (2004-08-01), None
D.A. Gedcke, Dealing with Dead Time Distortion in a Time Digitizer, ORTEC, p. 1-14.
Belov, Mikhail, E. et al, “Automated Gain Control and Internal Calibration with External Ion Accumulation Capillary Liquid Chromatography-Electrospray Ionization-Fourier Transform Ion Cyclotron Resonance.,” Anal. Chem., vol. 75 (No. 16), p. 4195-4205, (Aug. 15, 2003).
D. A. Gedcke, “Dealing with Dead Time Distortion in a Time Digitizer,” Application Note—AN57, ORTEC (USA), p. 1-15.

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