Method and apparatus for continuously monitoring the concentrati

Details Method and apparatus for continuously monitoring the concentrati Method and apparatus for continuously monitoring the concentrati

1995-05-05

1997-06-24

Sykes, Angela D.

Surgery

Truss

Pad

6048901, A61B 500

Patent

active

056409540

ABSTRACT:
The present invention is directed to a method and an apparatus for continuously monitoring the concentration of a metabolite, such as glucose or lactic acid, in biological tissue, in which a perfusion fluid is fed to a microdialysis probe implanted in the subcutaneous tissue and removed therefrom as dialysate after enrichment with the metabolites contained in the lymph. An enzyme is added to the dialysate and/or perfusion fluid, and the concentration of the metabolite in the dialysate is determined under the selective effect of the enzyme at a measuring point which is positioned ex vivo, using an electrochemical sensor. The enzyme is added to the dialysate in the form of a continuous enzyme solution flow upstream of the measuring point and in dependence of the throughput of the microdialysis probe.

REFERENCES:
patent: 3902970 (1975-09-01), Levin
patent: 4633878 (1987-01-01), Bombardieri
patent: 4671288 (1987-06-01), Gough
patent: 5106365 (1992-04-01), Hernandez
patent: 5109850 (1992-05-01), Blanco et al.
patent: 5126034 (1992-06-01), Carter et al.
patent: 5176632 (1993-01-01), Bernardi
patent: 5193545 (1993-03-01), Marsoner et al.
patent: 5298022 (1994-03-01), Bernardi
Schubert et al. "An Implantable Artifical Pancreas", Medical & Biological Engineering + Computing, vol. 18, No. 4, pp. 527-537, Jul. 1980.
K. Cammann: Das Arbeiten mit ionenselektiven Elektroden Springer-Verlag, Berlin Heidelberg New York 1977, pp. 100-106.
J. G. Schindler and M. V. Guelich: L-Lactat-Durchflusselektrode mit immobilisierter Lactat-Oxidase Fresenius Zeitschrift, Springer-Verlag 1981, pp. 434-436.
V.W. Mindt, et al.: Sensoren fuer Lactat und Glucose, Verlag Chemie GmbH, 1973, pp. 805-808.
P. Racine, et al.: An Instrument for the Rapid Determination of L-Lactate in Biological Fluids, Medical Instrumentation, vol. 9, No. 1, Jan.-Feb. 1975, pp. 11-14.

Affiliated with

Also associated with

Rating

Method and apparatus for continuously monitoring the concentrati does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and apparatus for continuously monitoring the concentrati, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for continuously monitoring the concentrati will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-144970