Method and apparatus for combined magnetophoretic and...

Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C204S643000

Reexamination Certificate

active

07033473

ABSTRACT:
Methods and apparatuses for discriminating matter utilizing dielectrophoresis combined with magnetophoresis. A sample having one or more constituents is injected into an inlet port of a chamber. A carrier medium flow is initiated at the inlet port to establish a flow within the chamber. A dielectrophoretic force is generated to act on the constituents of the sample. A magnetophoretic force is generated to act on the constituents of the sample. The dielectrophoretic force and magnetophoretic forces are balanced to position the constituents within the chamber. The constituents are then collected at one or more outlet ports of the chamber according to the dielectric and magnetic characteristics of the constituents. The constituents may be collected as a function of time-of-exit from the chamber and/or position within the chamber.

REFERENCES:
patent: 4001102 (1977-01-01), Batha et al.
patent: 4326934 (1982-04-01), Pohl
patent: 4440638 (1984-04-01), Judy et al.
patent: 4911806 (1990-03-01), Hofmann
patent: 5344535 (1994-09-01), Betts et al.
patent: 5454472 (1995-10-01), Benecke et al.
patent: 5489506 (1996-02-01), Crane
patent: 5569367 (1996-10-01), Betts et al.
patent: 5571401 (1996-11-01), Lewis et al.
patent: 5653859 (1997-08-01), Parton et al.
patent: 5683569 (1997-11-01), Chung et al.
patent: 5814200 (1998-09-01), Pethig et al.
patent: 5858192 (1999-01-01), Becker et al.
patent: 5888370 (1999-03-01), Becker et al.
patent: 5932097 (1999-08-01), Wilson
patent: 5965452 (1999-10-01), Kovacs
patent: 5993630 (1999-11-01), Becker et al.
patent: 5993631 (1999-11-01), Parton et al.
patent: 5993632 (1999-11-01), Becker et al.
patent: 6010616 (2000-01-01), Lewis et al.
patent: 6017696 (2000-01-01), Heller
patent: 6093308 (2000-07-01), Lewis et al.
patent: 6099803 (2000-08-01), Ackley et al.
patent: 6109119 (2000-08-01), Jiang et al.
patent: 6113768 (2000-09-01), Fuhr et al.
patent: 6129828 (2000-10-01), Sheldon, III et al.
patent: 6224745 (2001-05-01), Baltruschat
patent: 6225059 (2001-05-01), Ackley et al.
patent: 6287832 (2001-09-01), Becker et al.
patent: 6294063 (2001-09-01), Becker et al.
patent: 6790330 (2004-09-01), Gascoyne et al.
patent: 0513064 (1992-11-01), None
patent: 0625267 (1994-11-01), None
patent: 0680380 (1995-11-01), None
patent: 0691891 (1996-01-01), None
patent: 0898493 (1999-03-01), None
patent: 2266153 (1993-10-01), None
patent: 1-196566 (1989-08-01), None
patent: 5-126796 (1993-05-01), None
patent: 6018523 (1994-01-01), None
patent: 474723 (1975-06-01), None
patent: WO 90/08759 (1990-08-01), None
patent: WO 91/11262 (1991-08-01), None
patent: WO 93/16383 (1993-08-01), None
patent: WO 93/20927 (1993-10-01), None
patent: WO 94/16821 (1994-08-01), None
patent: WO 94/22583 (1994-10-01), None
patent: WO 95/13813 (1995-05-01), None
patent: WO 96/31282 (1996-10-01), None
patent: WO 97/34689 (1997-09-01), None
patent: WO 98/10267 (1998-03-01), None
patent: WO 99/62622 (1999-12-01), None
patent: WO 00/69565 (2000-11-01), None
Goater et al., “A combined travelling wave dielectgrophoresis and electrorotation device: applied to the concentration and viability determination of cryptosporidium,”J. Phys. D: Appl. Phys., 30:L65-L69, 1997.
Wang et al., “Dielectrophertic manipulation of cells with spiral electrodes,”Biophys. J., 72:1887-1899, 1997.
Wang et al., “Dielectrophoretic manipulation of particles,” presented at the instituted for electrical engineers industrial application society meeting, Orlando, FL, Oct. 1995.
Wang et al., “Non-uniform spatial distributions of both the magnitude and phase of AC electric fields determine dielectrophoretic forces,”Biochim. Biophys. Acta, 1243(2):185-194, 1995.
Wang et al., “Particle dipole—dipole interactions in AC electric fields,”Proc. 16thIEEE: Eng. Med. Biol. Soc., 774-775, 1994.
Wang et al., “Relationship of dielectrophoretic and electrorotational behaviour exhibited by polarized particles,”J. Phys. D: Appl. Phys.,25:905-912, 1992.
Wang et al., “Separation of polystyrene microbeads using dielectrophetic/gravitational field-flow-fractionation,”Biophysical Journal, 74:2689-2701, 1998.
Washizu et al., “Molecular dielectrophoresis of biopolymers,”IEEE Trans on Industry App., 30(4):835-843, 1994.
Washizu, “Electrostatic actuation of liquid droplets for microreactor applications,”IEEE Transactions on Industry Applications, 34(4):732-737, 1998.
Yang et al., “Cell separation on microfabricated electrodes using dielectrophoretic/gravitational field-flow fractionation,”Analytical Chem., 71(5): 911-918, 1999.
Yeh et al., “Effects of antraquinones of Polygonum cuspidatum on HL-60 cells,”Planta Medica, 54:413-414, 1988.
Zborowski et al., “Continuous cell separation using novel magnetic quadrupole flow sorter,”J. Mag.&Mag. Materials, 194:224-230, 1999.
Zhang and Hung, “Sensitization of HER-2/Neu overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin,”Oncogene, 12:571-576, 1996.
Zhang et al., “Suppressed transformation and induced differentiation of HER-2/Neu overexpressing breast cancer cells by emodin,”Cancer Res.,55:3890-3896, 1995.
Co-pending U.S. Appl. No. 09/883,110 by Peter R.C. Gascoyne et al., filed Jun. 14, 2001.
“Bangor biochip heads for California,” EPSRC Home Page: http://www.epsrc.ac.uk/documents/about—epsrc/corporate—publi.../bangor.ht, article printed on Dec. 26, 2000.
“Diagnostic dielectrophoresis-on-a-chip,”Science/Technology, 77(8):32, 1999. Article printed from http://pubs.acs.org/hotartcl/cenear/99022/7708scitobox2.html on Dec. 26, 2000.
Allsopp et al., “Impedance technique for measuring dielectrophoretic collection of microbiological particles,”J. Phys. D: Appl. Phys., 32:1066-1074, 1999.
Arnold and Zimmermann, “Rotation of an isolated cell in a rotating electric field,”Natu{overscore (r)}wissenschaften69 297-300, 1982.
Balachandran et al., “Electrostatic atomization of conducting liquids using AC superimposed on DC fields,”IEEE Transactions on Industry Applications,30(4):850-854, 1994.
Becker et al., “Separation of human breast cancer cells from blood by differential dielectric affinity,”Proc. Natl. Acad. Sci. USA, 92(3):860-864, 1995.
Becker et al., “The removal of human leukaemia cells from blood using interdigitated microelectrodes,”J. Phys. D. Appl. Phys., 27:2659-2662, 1994.
Cheng et al., “Preparation and hybridization analysis of DNA/RNA formE. colion microfabricated biolectronic chips,”Nature Biotechnology, 16:541-546, 1998.
Davis and Giddings, “Feasibility study of dielectrical field-flow fractionation,”Separation Science and Technology, 21(9):969-989, 1986.
De Gasperis et al., “Microfluidic cell separation by 2-D dielectrophoresis,”Biomedical Microdevices,2:11, 41-49, 1999.
El-Kishky and Gorur, “Electric field and energy computation on wet insulating surfaces,”IEEE Transaction on Dielectrics and Electrical Insulation, 3(4):587-593, 1996.
El-Kishky and Gorur, “Electric field computation on an insulating surface with discrete water droplets,”IEEE Transactions on Dielectrics and Electrical Insulation, 3(3):450-456, 1996.
Fuller et al., “Microfabricated multi-frequency particle impedance characterization system,”Micro Total Analysis System, 265-268, May 2000.
Galicki et al., “Electrohydrodynamic atomization of dielectric fluids,”Conference on Electrical Insulation and Dielectric Phenomena,IEEE Annual Report, 365-368, 1996.
Gascoyne et al., “A microfluidic device combining dielectrophoresis and field flow fractionation for particle and cell discrimination,”Proceedings of Solid State Sensor and Actuator Workshop, Hilton Head Supplement,37-38, 1998.
Gascoyne et al., “Cell separation by conventional dielectrophoresis combined with field-f

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and apparatus for combined magnetophoretic and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and apparatus for combined magnetophoretic and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for combined magnetophoretic and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3574922

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.