Combinatorial chemistry technology: method – library – apparatus – Method of creating a library
Reexamination Certificate
2006-11-14
2009-06-23
Low, Christopher (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of creating a library
C506S007000, C506S033000, C435S006120, C435S007100, C536S025300, C530S333000
Reexamination Certificate
active
07550410
ABSTRACT:
A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be photoactivated within a subset of channels at the site of immobilized substrate molecules or at a light-addressable site upstream from the substrate molecules. The method and apparatus of the invention find particularly utility in the synthesis of biopolymer arrays, e.g., oligonucleotides, peptides and carbohydrates, and in the combinatorial synthesis of small molecule arrays for drug discovery.
REFERENCES:
patent: 4820504 (1989-04-01), Battifora
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5556961 (1996-09-01), Foote et al.
patent: 5639603 (1997-06-01), Dower et al.
patent: 5661028 (1997-08-01), Foote
patent: 5763263 (1998-06-01), Dehlinger
patent: 5798035 (1998-08-01), Kirk et al.
patent: 6037186 (2000-03-01), Stimpson
patent: 6426184 (2002-07-01), Gao et al.
patent: 196174 (1986-10-01), None
patent: 373203 (1994-08-01), None
patent: WO 93/09668 (1993-05-01), None
patent: WO 94/08051 (1994-04-01), None
patent: WO 95/13538 (1995-05-01), None
patent: WO 95/16209 (1995-06-01), None
patent: WO 98/20967 (1998-05-01), None
patent: WO 99/19711 (1999-04-01), None
New Riverside Dictionary p. 248 1994.
Derwent Abstract No. 1999-288012 To Milstein WO 99/19711 Apr. 1994.
Banerjee et al. Protecting Groups that can be . . . , Journal of Organic Chemistry, v. 62, 6245-6251 1997.
Acetic acid, trichloro-, ester with 2-hydroxyacetophenone, CAS reg. No. 90724-05-3, data obtained from CAOLD in STN 1967.
Beatie et al., “Advances in genosensor research,” Clinical Chemistry, 41(5): 700-706, 1995.
Bunin and Ellman, “A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives.” J. Am. Chem. Soc., 114:10997-10998, 1992.
Bunin et al., “The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library,” Proc. Natl. Acad Sci. USA, 91(11):4708-4712, 1994.
Calvert and Pitts, Jr., Photochemistry, John Wiley & Sons, New York, pp. 550-555, 1966.
Chen et al., “Analogous organic synthesis of small-compound libraries: Validation of combinatorial chemistry in small-molecule synthesis,” J. Am. Chem. Soc., 116:2661-2662, 1994.
DeWitt et al., “Diversomers: An approach to nonpeptide, nonoligomeric chemical diversity,” Proc. Natl. Acad. Sci. USA, 90:6909-6913, 1993.
Dooley et al., “Acetalins: Opioid receptor antagonists determined through the use of synthesis peptide combinatorial libraries,” Proc. Natl. Acad. Sci. USA, 90(22):10811-10815, 1993.
Dooley et al., “The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands,” Life Sci., 52(18):1509-1517, 1993.
Drmanac et al., “DNA sequence determination by hybridization: A strategy for efficient large-scale sequencing,” Science, 260:1649-1652, 1993.
Eichler et al., Identification of substrate-analog trypsin inhibitors through the screening of synthetic peptide combinatorial libraries,: Biochemistry, 32(41):11035-11041, 1993.
Fodor et al., “Light-directed, spatially addressable parallel chemical synthesis,” Science, 251:767-773, 1991.
Furka et al., “General method for rapid synthesis of multicomponent peptide mixtures,” Int. J. Pept. Protein Res., 37:487-493, 1991.
Gao et al., “Oligonucleotide synthesis using solution photogenerated acids,” J. Am. Chem. Soc., 120, 12098-12099, 1998.
Geysen et al., “Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid,” Proc. Natl. Acad. Sci. USA, 81:3998-4002, 1984.
Geysen et al., “Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein,” Proc. Natl. Acad. Sci. USA, 82:178-182, 1985.
Green and Wuts, In: Protective Groups in Organic Synthesis, John Wiley & Sons, Inc., New York 1991.
Himmelsbach et al., “The p-nitrophenylethyl (NPE) group: A versatile new blocking group for phosphate and aglyeone protection in nucleosides and nucleotides,” Tetrahedron, 40:59-72, 1984.
Houghten et al., “Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery,” Nature, 354:84-86, 1991.
Houghten et al., “The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides,” BioTechniques, 13(3):412-421, 1992.
Kramer et al., Simultaneous synthesis of peptide libraries on single resin and continuous cellulose membrane supports: Examples for the identification of protein, metal and DNA binding peptide mixtures.: Pept. Res., 6(6):314-319, 1993.
Nestler et al., “A general method for molecular tagging of encoded combinatorial chemistry libraries,” J. Org. Chem., 59:4723-4724, 1994.
Pillai, “Photolytic deprotection and activation of functional groups,” Organic Photochemistry, Padwa, Ed., Marcel Dekker, Inc., New York, 9:225-323, 1987.
Pinilla et al., “Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.” Biotechniques, 13(6):901-905, 1992.
Pinilla et al., “Synthetic peptide combinatorial libraries (SPCLs): Identification of the antigenic determinant of β-endorphin recognized by monoclonal anibody 3E7,”Gene, 128 (1):71-76, 1993.
Southern et al., Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models. Genomics, 13:1008-1017, 1992.
Turro. In: Modern Molecular Photochemistry, The Benjamin/Cummings Publishing Co., Inc., Menlo Park, California, Chapter 10, pp. 362-411, 1978.
Low Christopher
Luedeka Neely & Graham PC
Lundgren Jeffrey S.
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