Method and apparatus for chromatography mass spectrometry

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical

Reexamination Certificate

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C702S002000

Reexamination Certificate

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07742879

ABSTRACT:
The results of mass spectrometry are compared; correspondences are established between individual components contained in different samples; the results of establishment of correspondences are checked; and varying components are extracted. At least two samples are compared with respect to the ion intensity corresponding to retention times and mass-to-charge ratios obtained by chromatography-mass spectrometry on the samples having a plurality of components. In ion groups observed as mass spectra, a correspondence between the retention times at which the same component is supposed to be observed is established by determining coincidence between the mass-to-charge ratios and determining that the ion intensity fall within a designated variation.

REFERENCES:
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patent: WO 2006/077160 (2006-07-01), None
Ono, M., et al., “Label-free quantitative proteomics using large peptide data sets generated by nano-flow liquid chromatography and mass spectrometry,” MCP Papers in Press, Mar. 21, 2006, p. 1-24, fig. 1-4, Manuscript T500039-MCP200, The American Society for Biochemistry and Molecular Biology, Inc.
Japanese Office Action issued in Japanese Patent Application No. JP 2007-090058 dated Jul. 21, 2009.
Japanese Notice of Rejection issued in Japanese Patent Application No. JP 2007-090058 dated Nov. 24, 2009.

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