Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2005-05-24
2005-05-24
Smith, Ruth S. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S410000, C600S420000, C600S425000, C600S431000, C128S920000, C700S090000, C702S019000
Reexamination Certificate
active
06898453
ABSTRACT:
A method for determining tissue type includes quantitatively determining a tissue blood flow (TBF) by deconvoluting Q(t) and Ca(t), where Q(t) represents a curve of specific mass of contrast, and Ca(t) represents an arterial curve of contrast concentration, and quantitatively determining a tissue blood volume (TBV) by deconvoluting Q(t) and Ca(t). The method also includes quantitatively determining a tissue mean transit time (TMTT) by deconvoluting Q(t) and Ca(t), and quantitatively determining a tissue capillary permeability surface area product (TPS) by deconvoluting Q(t) and Ca(t). The method also includes determining a tissue type based on the TBF, the TBV, the TMTT, and the TPS.
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Cenic A. et al.: “A CT Method to Measure Hemodynamics in Brain Tumors: Validation and Application of Cerebral Blood Flow Maps,” American Journal of Neuroradiology, United States, Mar. 2000, pp. 462-470.
Ostergaard L. et al.: “High Resolution Measurement of Cerebral Blood Flow using Intravascular Tracer Bolus Passages. Part I: Mathematical Approach and Statistical Analysis,” Magnetic Resonance in Medicine, Academic Press, Duluth, MN, US, pp. 715-725.
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Armstrong Teasdale LLP
Horton Esq. Carl B.
Smith Ruth S.
The John P. Robarts Research Institute
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