Chemistry: analytical and immunological testing – Optical result
Reexamination Certificate
2007-05-15
2007-05-15
Chin, Christopher L. (Department: 1641)
Chemistry: analytical and immunological testing
Optical result
C436S516000, C436S805000
Reexamination Certificate
active
10253846
ABSTRACT:
Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.
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Liu, et al., “Development of an optical fiber lactate sensor”, Mikrochimica Acta, 1999, 131(1-2), pp. 129-
Cunningham Brian
Karl William C.
Li Peter
Pien Homer
Puff Derek
Chin Christopher L.
McDonnell Boehnen & Hulbert & Berghoff LLP
SRU Biosystems Inc.
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