Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1993-10-01
1998-01-06
Fleisher, Mindy
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530333, 530334, 530335, 530337, 536 253, 536 2531, 536 2532, 536 2533, 536 2534, C07K 102, C07K 104, C07K 106, C07H 2104
Patent
active
057056102
ABSTRACT:
Method and apparatus for synthesizing biopolymers, such as polypeptides and polynucleotides. The apparatus includes plural reaction vessels in which subunit coupling to biopolymers in a particle suspension is carried out. The vessels are connected to common valving structure for use in mixing the suspension and removing suspension liquid. In one embodiment, a robotic arm in the apparatus is operable to transfer reaction solution to the reaction vessels, and to transfer particle suspensions from the reaction vessels to a mixing vessel and back to the reaction vessels. The method can be used to produce preferably equi-molar amounts of different-sequence biopolymers, such as polypeptides and polynucleotides.
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Heubner Verena D.
Santi Daniel V.
Siani Michael A.
Zuckermann Ronald N.
Blackburn Robert P.
Chiron Corporation
Degen Nancy J.
Fleisher Mindy
Green Grant D.
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