Radiant energy – Invisible radiant energy responsive electric signalling – Infrared responsive
Patent
1996-01-16
1997-02-25
Porta, David P.
Radiant energy
Invisible radiant energy responsive electric signalling
Infrared responsive
25033907, 25033912, G01J 3457
Patent
active
056061641
ABSTRACT:
A method and apparatus for measuring the concentration of an analyte present in a biological fluid is disclosed. The method includes the steps of applying NIR radiation to calibration samples to produce calibration data, analyzing the calibration data to identify and remove outliers, constructing a calibration model, collecting and analyzing unknown samples to identify and remove outliers, and predicting analyte concentration of non-outliers from the calibration model. Analysis of the calibration data includes data pretreatment, data decomposition to remove redundant data, and identification and removal of outliers using generalized distances. The calibration model may utilize principal component regression, partial least squares, multiple linear regression, or artificial neural networks, and reduction using principal component analysis or partial least squares scores. Unknown sample data is analyzed using data pretreatment followed by projection into the calibration model space, and identification and removal of outliers, with prediction of analyte concentration using the calibration model. The apparatus includes a pump which circulates a sample through tubing to fill a flowcell. Light from a NIR source is synchronized with a detector, facilitating light and dark measurements, and passes through a monochrometer and the flowcell and strikes the detector, whereby radiation transmitted through the sample is measured. Measurement data is stored in a general purpose programmable computer also controlling the pump, the detector, synchronization, and the monochrometer. The computer includes a general purpose microprocessor configured with computer program code employing the steps of the method.
REFERENCES:
patent: 4660151 (1987-04-01), Chipman et al.
patent: 4661913 (1987-04-01), Wu et al.
patent: 4975581 (1990-12-01), Robinson et al.
patent: 5047323 (1991-09-01), Colman et al.
patent: 5121338 (1992-06-01), Lodder
patent: 5199439 (1993-04-01), Zimmerman et al.
patent: 5210778 (1993-05-01), Massart
patent: 5252489 (1993-10-01), Macri
patent: 5258907 (1993-11-01), Macri
patent: 5308982 (1994-05-01), Ivaldi et al.
patent: 5316953 (1994-05-01), Macri
patent: 5324667 (1994-06-01), Macri
patent: 5324668 (1994-06-01), Macri
patent: 5348002 (1994-09-01), Caro
patent: 5348003 (1994-09-01), Caro
patent: 5355880 (1994-10-01), Thomas et al.
patent: 5379764 (1995-01-01), Barnes et al.
S. Wold and M. Sjorstorm, article entitled SIMCA: A Method for Analyzing Chemical Data in Terms of Similarity and Analogy, in Chemometrics: Theory and Application, B. R. Kowalski, Ed., American Chemical Society, Washington, D.C. 242-282, (1977). No Month.
H. L. Mark and D. Tunnell, Qualitative Near-Infrared Reflectance Analysis Using Mahalanobis Distances, Analytical Chemistry 57, 1449-1456, (1985). No Month.
E. R. Malinowski, Theory of the Distribution of Error Eigenvalues Resulting from Principal Component Analysis with Application to Spectroscopic Data, Journal of Chemometrics, 1, 33-40, (1987). No Month.
D. M. Haaland and E. V. Thomas, Partial Least-Squares Methods for Spectral Analyses, 1, Relation to Other Quantitative Calibration Methods and the Extraction of Qualitative Information, Analytical Chemistry, 60, 1193-1202, (1988). No. Month.
N. K. Shah and P. J. Gemperline, Combination of the Mahalanobis Distance and Residual Variance Pattern Recognition Techniques for Classification of Near-Infrared Reflectance Spectra, Analaytical Chemistry, 62, 465-470, (1990). No Month.
Long James R.
Price John F.
Boehringer Mannheim Corporation
Bruce David Vernon
Porta David P.
Reynolds Locke
LandOfFree
Method and apparatus for biological fluid analyte concentration does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for biological fluid analyte concentration , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for biological fluid analyte concentration will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1975758