Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2011-04-12
2011-04-12
Ketter, James S (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S470000, C435S471000, C435S173600
Reexamination Certificate
active
07923251
ABSTRACT:
The present invention provides a method and apparatus for transferring an agent into a cell. The method includes the steps of providing an agent outside of a cell and generating a vapor bubble and a plasma discharge between an avalanche electrode and a conductive fluid surrounding the cell. The vapor bubble and plasma discharge generate a mechanical stress wave and an electric field, respectively. The combination of this mechanical stress wave and electric field results in permeabilization of the cell, which in turn results in transfer of the agent into the cell.
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Chalberg, Jr. Thomas W.
Huie, Jr. Philip
Palanker Daniel V.
Vankov Alexander
K&L Gates LLP
Ketter James S
The Board of Trustees of the Leland Stanford Junior University
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