Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2006-09-19
2006-09-19
Wells, Nikita (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S281000, C250S285000, C250S287000, C250S42300F
Reexamination Certificate
active
07109478
ABSTRACT:
The present invention provides an apparatus and method for automated and rapid loading of a large number of samples for mass spectrometric analysis using various ionization methods (e.g. matrix assisted desorption by laser bombardment (MALDI) and atmosperic pressure ionization (API) methods such as electrospray). The aparatus utilizes microtiter plates to hold the sample, optical elements (e.g. fiber optic) to facilitate automated transport of the ions, and a multiple part capillary comprising at least two capillary sections joined with airtight seal by a union for use in mass spectrometry (particularly with ionization sources) to transport ions between pressure regions of a mass spectrometer for analysis is described herein. Preferably, the capillary is useful to transport ions from an elevated pressure ionization source to a first vacuum region of a mass analysis system.
REFERENCES:
patent: 4391778 (1983-07-01), Andresen et al.
patent: 5495108 (1996-02-01), Apffel, Jr. et al.
patent: 5580434 (1996-12-01), Robotti et al.
patent: 5652427 (1997-07-01), Whitehouse et al.
patent: 5663561 (1997-09-01), Franzen et al.
patent: 5750988 (1998-05-01), Apfel et al.
patent: 5753910 (1998-05-01), Gourley et al.
patent: 5965883 (1999-10-01), Lee et al.
patent: 6359275 (2002-03-01), Bertsch et al.
patent: 6410914 (2002-06-01), Park et al.
patent: 6515280 (2003-02-01), Baykut
patent: 6777672 (2004-08-01), Park
patent: 6787764 (2004-09-01), Park
patent: 6794644 (2004-09-01), Park
V. Laiko, M Baldwin and A. Burlingame, Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Anal. Chem., vol. 72, No. 4, Feb. 4, 2000.
Schevchenko et al., MALDI Quadrupole Time-of-Flight Mass Spectrometry: A Powerful Tool for Proteomic Research, Analytical Chemistry, vol. 72, No. 9, May 1, 2000.
Bruker Daltonics Inc.
Ward & Olivo
Wells Nikita
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