Optics: measuring and testing – By light interference – Holography
Reexamination Certificate
2011-05-24
2011-05-24
Lyons, Michael A (Department: 2877)
Optics: measuring and testing
By light interference
Holography
Reexamination Certificate
active
07948632
ABSTRACT:
A non-destructive method and device for analyzing a sample comprising transparent living and/or dead cells, by 5 means of a digital holographic microscope, where the sample (8) is exposed to light from a laser (2). The light that travels through the cells in the sample will experience a difference in the optical path length compared to the surrounding media and the wave front that emerges from the 10 cells will thus be phase shifted. This distortion can be detected in the digital hologram, which is reconstructed from the interference pattern detected by a digital sensor (17), such as a CCD or a CMOS, as phase differences or phase shifts and thereby creating a digital hologram. The 15 phase shift of each element of the hologram is then used for analyzing the characteristics of the cells in the sample.
REFERENCES:
patent: 6943924 (2005-09-01), Marquet et al.
patent: 7460240 (2008-12-01), Akcakir
patent: 2005-141186 (2005-06-01), None
patent: WO 2005/033679 (2005-04-01), None
Marquet, Pierre et al. “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy”. Optics Letters, vol. 30, No. 5, Mar. 1, 2005, pp. 468-470.
Carl et al. “Parameter-optimized digital holographic microscope for high-resolution living-cell analysis.”Applied Optics. vol. 43. No. 36. 2004. pp. 6536-6544.
Schnars. “Direct phase determination in hologram interferometry with use of digitally recorded holograms.”Jr. of the Optical Society of America. vol. 11. No. 7. 1994. pp. 2011-2015.
Chinese Office Action for corresponding Chinese Patent Application No. 200680048900.7, mailed Jul. 26, 2010. English translation.
Supplementary European Search Report for corresponding European Patent Application No. 06844041.1-2205/1963927, mailed Jul. 29, 2010.
Gustafsson Mats
Sebesta Mikael
Lyons Michael A
Merchant & Gould P.C.
Phase Holographic Imaging PHI AB
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