Surgery – Truss – Perineal
Patent
1977-02-24
1978-06-13
Howell, Kyle L.
Surgery
Truss
Perineal
128 2T, A61B 504
Patent
active
040943070
ABSTRACT:
A method and apparatus for synthesizing a set of optimal sensory stimuli designed to elicit an optimal response for each particular brain electrode location in a subject whose brain is being examined to anatomically localize brain dysfunction. A pseudorandom input signal having the general characteristics of Gaussian white noise is generated and converted into a color video visual stimulus which can be observed by the subject and summed on his retina and associated neural network. A plurality of electrodes are positioned with respect to various different and distinct areas of the brain of the subject to be examined. The subject is shown the color video visual stimulus and the electrical analog response from the electrodes is amplified and stored. The stored analog response signals are cross-correlated with the resynthesized input signal to compute a Wiener kernel representation of the response for each electrode. Portions of the pseudorandom input signal which resulted in insignificant analog responses are masked out so that the subsequent generation of pseudorandom input signals will be bandwidth-limited. The analog responses to the bandwidth-limited visual stimulus are cross-correlated with the resynthesized masked input signal and new Wiener kernel representations are recomputed for each electrode. The recomputed Wiener kernel representations of the response from each electrode are then multiplied in an array processor with the resynthesized bandwidth-limited input signal to compute an optimum visual stimulus for each of the electrodes. These optimum visual stimuli may be subsequently displayed to the subject alone or in conjunction with psychophysical tests to aid in anatomically localizing dysfunction in a brain under examination.
REFERENCES:
patent: 3147373 (1964-09-01), Clynes
patent: 3498287 (1970-03-01), Ertl
Troelstra, Arne et al., "The Electrical Response of the Human Eye to Sinusoidal Light Stimulation", IEEE Trans on Biomed Engr. VBME22, #5, Sep. 1975, pp. 369-378.
Williams, W. J. et al., "Biological System Transfer-Function Extraction using Swept-Frequency and Correlation Techniques", Med. & Biol. Engr., 1972, v. 10, #5, pp. 609-620.
Marmarelis, P. Z. et al., "White-Noise Analysis of a Neuron Chain: An application of the Wiener Theory" - Science, 1972, #175, pp. 1276-1278.
Howell Kyle L.
Jaworski Francis J.
Padgett, Jr. Charles P.
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