Method and apparatus for a combination of electroporation and io

Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...

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935 52, 4351736, A61N 130

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active

060093455

ABSTRACT:
An apparatus for transdermal molecular delivery, comprises a first electrode assembly having an anode and a cathode in closely spaced relation for engaging the stratum corneum through which to apply an electric field, first power supply including a first circuit connected to the first electrode assembly for applying a pulsed electric field of sufficient amplitude to induce pores in the stratum corneum, a second electrode assembly spaced from the first electrode assembly and comprising at least one of an anode and a cathode, second power supply including a second circuit connected to the first electrode assembly and the second electrode assembly for applying a low voltage continuous electric field of a preselected polarity and sufficient amplitude to induce migration of molecules through pores in the stratum corneum.

REFERENCES:
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5318514 (1994-06-01), Hofmann
patent: 5439440 (1995-08-01), Hofmann
patent: 5464386 (1995-11-01), Hofmann
patent: 5688233 (1997-11-01), Hofmann et al.

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