Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1995-06-07
1998-09-22
Railey, II, Johnny F.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
435 4, A61K 4900, C12Q 100
Patent
active
058110755
ABSTRACT:
The present invention relates to a method and associated agents for the inhibition and treatment of protein aging in animals by stimulating the bodies of the animals to increase their recognition and affinity for advanced glycosylation end products. Specifically, the method contemplates the administration of certain agents such as advanced glycosylation endproducts, such endproducts as are bound to the carrier, monokines that stimulate phagocytic cells to increase their activity toward advanced glycosylation endproducts, and mixtures of these materials either alone, or in conjunction with other co-stimulatory agents. Numerous diagnostic and therapeutic applications are defined, and pharmaceutical compositions are also contemplated.
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Brownlee Michael
Cerami Anthony
Vlassara Helen
Railey II Johnny F.
The Rockefeller University
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