Method and agents for promoting wound healing

Details Method and agents for promoting wound healing Method and agents for promoting wound healing

1991-02-07

1992-09-08

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Lymphokine

514 12, 514 21, A61K 3700

Patent

active

051456761

ABSTRACT:
The present invention relates to the treatment of wound healing dysfunction by the administration of one or more would healing modulators. The wound healing modulator may be selected from appropriate wound healing agents and binding partners, and particularly agents that enhance wound healing. The agent may comprise a cytokine, or mixture of cytokines that are also capable of binding to heparin, and inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously. Particular agents comprise the inflammatory cytokines MIP-1, MIP-1.alpha., MIP-1.beta. and MIP-2. Diagnostic and therapeutic utilities are proposed, and pharmaceutical compositions are likewise set forth.

REFERENCES:
patent: 4603106 (1986-07-01), Ceremi et al.
Deuel et al. PNAS, USA vol. 78, No. 7, pp. 4584-4587, Jul. 1981.

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