Method and agents for preventing staining of teeth

Details Method and agents for preventing staining of teeth Method and agents for preventing staining of teeth

1990-10-26

1992-07-07

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Dentifrices

433216, 424 50, 424 51, 424 52, 424 53, 424 54, A61K 716

Patent

active

051281228

ABSTRACT:
The present invention relates to methods and agents for preventing the staining of teeth caused by the nonenzymatic browning of proteins in the oral cavity. Both oral and parenteral administration ft the agents are disclosed. Suitable agents for the inhibition of nonenzymatic browning may be formulated as rinses and toothpastes, and include compounds capable of reacting with the carbonyl moiety of the early glycosylation product resulting from the initial reaction of a target protein in the nonenzymatic browning reaction. Preferred agents are those having an active nitrogen-containing substituent, as well as amino acids, their esters and amides. These preparations may further include known anti-plaque agents such as chlorhexidine.

REFERENCES:
patent: 4908446 (1990-03-01), Ulrich et al.
patent: 4978684 (1990-12-01), Cerami et al.

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