Drug – bio-affecting and body treating compositions – Dentifrices – Ammonia – amine – or derivative thereof
Patent
1990-10-30
1992-03-17
Willis, Prince E.
Drug, bio-affecting and body treating compositions
Dentifrices
Ammonia, amine, or derivative thereof
A61K 722
Patent
active
050967037
ABSTRACT:
The present invention relates to methods and agents for preventing the staining of teeth caused by the nonenzymatic browning of proteins in the oral cavity. Both oral and parenteral administration of the agents are disclosed. Suitable agents for the inhibition of nonenzymatic browning may be formulated as rinses and toothpastes, and include compounds capable of reacting with the carbonyl moiety of the early glycosylation product resulting from the initial reaction of a target protein in the nonenzymatic browning reaction. Preferred agents are those having an active nitrogen-containing substituent, as well as amino acids, their esters and amides. These preparations may further include known anti-plaque agents such as chlorhexidine.
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Cerami Anthony
Yamin Michael A.
Johnson Jerry D.
The Rockefeller University
Willis Prince E.
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