Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Aldehyde doai
Patent
1998-04-17
2000-02-15
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Aldehyde doai
514724, A61K 31045, A61K 3111
Patent
active
060254017
ABSTRACT:
The present invention relates to compositions and methods for inhibiting the aging of amino-containing amino acid, peptides, proteins and biomolecules. Accordingly, a composition is disclosed which comprises an agent or compound capable of reacting with the glycosyl-amino moiety of the early glycosylation product (also known as the Amadori product or the Heyns product) formed by the reaction of glucose, or other reactive sugars, with an amino-containing peptide, protein or biomolecule, thus stabilizing this early glycosylation product, and preventing its further reaction to form open-chain, carbonyl-containing advanced glycosylation end products. Suitable agents may contain a reactive aldehyde group. A preferred agent is acetaldehyde. The method comprises contacting the target biomolecule with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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Abed Yousef Al
Bucala Richard J.
Cerami Anthony
Ulrich Peter C.
Russel Jeffrey E.
The Picower Institute for Medical Research
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