Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-05-03
1984-07-31
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
A61K 3700
Patent
active
044629893
ABSTRACT:
A method and associated agents for the arrest of infections resulting from organism growth in contact with an iron-containing body fluid, comprising administering an agent capable of immobilizing the body fluid so that the iron it contains is nutritionally unavailable for the organism. In the instance where the body fluid is blood, the agent may be administered in amounts effective to bind all of the available red blood cells or hemoglobin, to prevent breakdown of either and consequent release of iron to the organism.
The agents preferably include materials capable of binding red blood cells and iron, such as haptoglobin, colloidal silica, anion exchange resins and mixtures thereof. Preferably, colloidal silica is used either alone or in a composite with a polyolefin elastomer such as polyisobutylene.
The agents may be coated on carriers or substrates, such as gauze pads, tampons and the like, and may be thus utilized topically, as well as intraperitoneally.
REFERENCES:
patent: 4061735 (1977-12-01), Funakoshi et al.
patent: 4113853 (1978-09-01), Funakoshi et al.
patent: 4137307 (1979-01-01), Funakoshi et al.
Graziano, J. H. et al., "The Identification of 2,3-Dihydroxybenzoic Acid as a Potentially Useful Iron-Chelating Drug" J. Pharmacol. Exp. Therap. 190:570-575, 1974.
White, G. P. et al., "The Effect of Chelating Agents on Iron Mobilization in Chang Cell Cultures" Blood 48:923-929, 1976.
Grady, R. W. et al., "Development of New Iron-Chelating Drugs", Part II, J. Pharmacol. & Exper. Therap., 205:757-765, 1978.
Grady, R. W. et al., "The Current Status of Iron Chelation", Ann. Rev. Med. Chem. 13:219-226, 1978.
Hershko, C. et al., "Mechanism of Iron Chelation in the Hypertransfused Rat: Definition of Two Alternative Pathways of Iron Metabolism", J. Lab. Clin. Med. 92:144-151, 1978.
Bhargava, K. K. et al., "New Compounds: N.sup.1, N.sup.8 -bis-(2,3-dihydroxybenzoly)-Spermidine and Several Analogues-Potential Iron-Chelating Drugs", J. Pharm. Sci. 69-986-989, 1980.
Jones, R. L. et al., "A Low Molecular Weight Iron Binding Factor from Mammalian Tissue which Potentiates Bacterial Growth in Vitro and in Vivo", J. of Exp. Med. 151:148-428, 1980.
Pagano, M. et al., "Kinetic Study of the Interaction Between Rat Haptoglobin and Rat Liver Cathepsin B", Can. J. Biochem. 58:410-417, (1980).
Eaton, J. et al., "Haptoglobin: A Natural Bacteriostat", Science, 215:691-693 (1982).
Eaton, J. W. et al., "Haptoglobin Prevents Lethal Hemoglobin-Driven Bacterial Peritonitis" (abstract submitted to American Society of Hemotology on Sep. 24, 1981).
D. Falkenhagen et al., "Serum Complement and Protein Metabolism in Chronic Dialysis Patients", Int. J. Art. Org. 2(2) at 65-68 (1979).
F. Wesenberg, "Characterization of Heat Eluates of Human Malignant Tissues", Acta Path. Microbiol Scand., Sect. C, 87 at 301-306 (1979).
F. Archibald et al., "Removal of Iron from Human Transferring by Neisseria Meningitidis", Fems Microbiol. Letters 6 at 159-162 (1979).
G. Calver et al., "Inhibition of the Growth of Neisseria Meningitidis by Reduced Ferritin and Other Iron-Binding Agents", Inf. and Imm. 25(3) at 880-890 (1979).
J. Davis et al., "A Possible Toxic Factor in Abdominal Injury", J. Trauma, 2:291-300 (1962).
Litwin et al., "Synergistic Toxicity of Gram-Negative Bacteria and Free Colloidal Hemoglobin", Ann. Surg., 157(4):485-493 (1963).
T. Hau et al., Surgery, 86(5):588-592 (1980).
J. Fletcher, "The Effect of Iron and Transferrin on the Killing of Escherichia coli in Fresh Serum", Immunol., 20:493-500 (1971).
A. Trippestad et al., "The Role of Hemoglobin for the Lethal Effect of Intestinal Strangulation Fluid", J. Surg. Res., 10(10):465-470 (1970).
J. J. Bullen et al., "The Effect of Iron Compounds on the Virulence of Escherichia coli for Guinea-Pigs", Immunol., 15:581-588 (1968).
G. H. Bornside et al., "Hemoglobin and Escherichia coli, a Lethal Intraperitoneal Combination", J. Bact., 95(5): 1567-1571 (1968).
T. Hau et al., Surgery, 83(2):223-229 (1978).
J. T. Lee, Jr. et al., Surgery, 86(1):41-48 (1979).
J. H. Davis et al., "A Toxic Factor in Abdominal Injury II: The Role of the Red Cell Component", J. Trauma, 4:84-90 (1964).
J. Eisenlauer et al., "Stability of Colloidal Silica (Aerosil) Hydrosols, I. Preparation and Characterization of Silica (Aerosil) Hydrosols", J. Colloid Interface Sci., 74(1):108-119 (1980).
J. Eisenlauer et al., "Stability of Colloidal Silica (Aerosil) Hydrosols, II Influence of the pH Value and the Adsorption of Polyethylene Glycols", J. Colloid and Interface Sci., 74(1):120-135 (1980).
B. E. Hallaway et al., "Changes in Conformation and Function of Hemoglobin and Myoglobin Induced by Adsorption to Silica", Biochem. Biophys. Res. Comm., 86(3):689-696 (1979).
Bobis Daniel H.
Evreka Inc.
Jackson David A.
Moezie F. T.
Phillips Delbert R.
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