Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1986-01-08
1988-09-27
Rosen, Sam
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
435 2, A61K 3514, A61K 3518
Patent
active
047740884
ABSTRACT:
A method for improving the quality and/or increasing the shelf-life of whole blood and red blood cell concentrates during storage thereof comprising manipulating the activities of the key red cell enzymes involved in the biosynthesis and degradation of 2,3-DPG (DPGM, DPGP, PGP) and in regulation of glycolysis (PK and PFK). The enzymes are manipulated, i.e. activated or inhibited, either singly or in combination. Such manipulations are achieved by adding to the whole blood or red blood cell concentrates an effective amount of one or more compounds which primarily inhibit the activity of PK and secondarily inhibit the activity of DPG phosphatase and maintain those of phosphofructokinase, phosphoglycolate phosphatase and DPG mutase. Among the compounds which can be used are L-amino acids, free fatty acids, glycolytic intermediates including analogs and derivatives of phosphoenolpyruvate, and free bases, inhibitors of DPGP as well as structural analogs and derivatives of all of the above compounds. Another compound which can be used to improve the quality of stored blood is a pyrophosphate compound.
REFERENCES:
patent: 3925153 (1975-12-01), Laborit
patent: 4112070 (1978-09-01), Harmening
patent: 4476221 (1984-10-01), Kane et al.
patent: 4572899 (1986-02-01), Walker et al.
patent: 4609372 (1986-09-01), Carmen et al.
Merck Index-ninth edition (1976), p. 1039.
Rosen Sam
The United States of America as represented by the Deptment of H
LandOfFree
Method and additives for improving the quality and shelf life of does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and additives for improving the quality and shelf life of, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and additives for improving the quality and shelf life of will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2397219