Method and a tobramycin aerosol formulation for treatment preven

Details Method and a tobramycin aerosol formulation for treatment preven Method and a tobramycin aerosol formulation for treatment preven

1997-04-02

2000-07-04

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514924, 424 43, A61K 3170

Patent

active

060839228

ABSTRACT:
A method for treatment, prevention and containment of acute and chronic tuberculosis using a preservative-free concentrated tobramycin aerosol formulation delivering tobramycin to the lung endobronchial space including alveoli in an aerosol having mass medium average diameter predominantly between 1 to 5.mu.. The method comprises administration of tobramycin in concentration one to ten thousand times higher than the minimal inhibitory concentration of Mycobacterium tuberculosis. A method for containment of and decreasing infectivity periods of tuberculosis patients to shorter periods of time.

REFERENCES:
patent: 4761402 (1988-08-01), Williams et al.
patent: 5006343 (1991-04-01), Benson et al.
patent: 5284133 (1994-02-01), Burns et al.
patent: 5508269 (1996-04-01), Smith et al.
Arnold L. Smith, M.D., et al., Safety of Aerosol Tobramycin Administration for 3 Months to Patients With Cystic Fibrosis, Pediatric Pulmonolgy, 7:265-271 (1989).

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