Method and a system for predicting protein functional site,...

Details Method and a system for predicting protein functional site,... Method and a system for predicting protein functional site,...

2007-05-31

2010-10-26

Hutson, Richard G (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S483000

Reexamination Certificate

active

07820423

ABSTRACT:
The present application provides a method for predicting the functional site of a protein using data of the entire proteins of an organism of which genome data or cDNA data is known. More specifically, the present application provides a method for predicting a protein functional site, comprising the steps of calculating the frequency of occurrence of an oligopeptide in the entire proteins, calculating the value of each amino-acid residue contributing to the frequency of occurrence as the representative value of the function, and predicting the protein functional site by using the representative value of function as an indicator. The present also provides a system for predicting a functional site for automatically performing said methods. Additionally, the present application provides a method for preparing a function-modified protein comprising subjecting the amino-acid residues composing the functional site identified by the method described above to artificial mutation, and a novel thermophilic DNA polymerase prepared by the method.

REFERENCES:
patent: 5489523 (1996-02-01), Mathur
Ngo et al. in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Zhang et al., From fold predictions to function predictions: Automation of functional site conservation analysis for functional genome predictions, Protein Science, vol. 8, No. 5, pp. 1104-1115 (1999).
Tatusov et al., “Metabolism and evolution of Haemophilus influenzae deduced from whome-genome comparision withEscherichia coli”,Current Biology vol. 6, No. 3, pp. 279-291 (1996).

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