Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1988-12-06
1992-07-07
Lacey, David L.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 30, 435 34, 4351721, 4352402, 4353201, 935 55, 935 66, C12N 500, C12N 1500, C12Q 104, C12Q 124
Patent
active
051282550
ABSTRACT:
The invention provides methods and products equal in a selection system for determining the presence or absence of a vector in a mammlian cell. The vector of the invention carries and is capable of expressing a gene encoding a protein capable of effecting the conversion of a precursor to an essential amino acid. A mammalian cell line is created with conditions capable of causing the vector to be introduced into the mammalian cell line. Then, the created mammalian cell line is grown in medium containing a precursors to the essential amino acid but not containing the growth-supporting amount of the essential amino acid and those cells capable of growing are selected.
REFERENCES:
Jouanneau et al. 1985, Eur. J. Biochem. 146(1) pp. 173-178.
Lehninger, 1975, Biochemistry, Worth Publishers, Inc.
Hartman, S. C. and Mulligan R. C., "Two Dominant-Acting Selectable Markers for Gene Transfer Studies in Mammalian Cells", Proc. Natl. Acad. Sci. USA, vol. 85, pp. 8047-8051, Nov., 1988.
Gentest Corporation
Lacey David L.
Wang Gian
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