Method and a kit for the assay of antibodies to soluble antigens

Details Method and a kit for the assay of antibodies to soluble antigens Method and a kit for the assay of antibodies to soluble antigens

1982-04-30

1984-08-28

Turk, Arnold

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Separation of immune complex from unbound antigen or antibody

436543, 436815, G01N 3354

Patent

active

044684703

ABSTRACT:
The invention relates to a method for the assay of antibodies to soluble antigens in an aqueous sample, in particular in body fluids, such as blood serum or blood plasma, by contacting said sample with an antigen in vitro, wherein antibodies, if present, are bound by said antigens. The invention furthermore relates to a kit for the assay and detection of antigen-specific antibodies.
According to the invention an antigen is used that is modified with a recognizable group, and said modified antigen is soluble in the test sample.
The interaction between antigen and antibody takes place in homogeneous solution.

REFERENCES:
patent: 3773625 (1973-11-01), Sternberger et al.
patent: 3966898 (1976-06-01), Sjoquist et al.
patent: 4021534 (1977-06-01), Lafontaine
patent: 4228237 (1980-10-01), Mevey et al.
patent: 4230797 (1980-10-01), Boguslaski et al.
patent: 4232119 (1980-11-01), Carksson et al.
patent: 4243749 (1981-01-01), Sadeh et al.

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