Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-12-27
1993-10-05
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514263, 514381, 514457, 514510, 514579, 514650, A61K 31495, A61K 3141, A61K 3135, A61K 3121, A61K 3113, A61K 31135
Patent
active
052505294
ABSTRACT:
A method of preventing or alleviating a migraine headache which comprises administering a pharmaceutically effective amount of a mast cell degranulation blocking agent just prior to or during the prodromal phase of the migraine in the absence of an analgesic. The agent can also be administered in combination with a central nervous system stimulant.
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International Search Report, Application No. PCT/US92/11227, including following references: W. Split, et al., "Ketotifen in the Treatment of Chronic Cluster Headache," Headache, 24:147-149, vol. 3, May 1984.
W. Split, et al., "Ketotifen (Zaditen) in the Therapy of Cluster Headache," Rev. Roum. Med. 1983, 21(3), pp. 253-256.
W. Split, et al., "Neurologia", Neurol. Neurochir. Pol., vol. 18, No. 2, 1984, pp. 105-109.
C. I. Parodi, et al., "Terfenadine Prophylaxis in Migraine", Acch. Psicol. Neurol. Psichiatr., vol. 49, No. 3, pp. 299-303.
W. D. Singer, "Pharmacological Management of Posttraumatic Headaches", J. Head Traum. Rehabil., vol. 4, No. 1, 1989, pp. 83-86.
Merck Index, 11th Edition, #4771, p. 645, Hydroxyzine (1983).
Current Therapy, "Headache" pp. 788-793 (1981).
Tek, Deniz, "The Effectiveness of Nalbuphine and Hydroxyzine for Emergency Treatment of Severe Headache", Annals of Emer. Med. Mar. 1987, pp. 107-112.
KOS Pharmaceuticals, Inc.
Waddell Frederick E.
Weddington K.
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