Methionine.sup.5 -enkephalin sulfoxides and sulfones

Details Methionine.sup.5 -enkephalin sulfoxides and sulfones Methionine.sup.5 -enkephalin sulfoxides and sulfones

1976-05-07

1979-03-13

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

041442288

ABSTRACT:
Methionine.sup.5 -enkephalin sulfoxides and sulfones having agonist activity at opiate receptors are disclosed herein. These sulfoxides and sulfones are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.

REFERENCES:
patent: 3853838 (1974-12-01), Greven
patent: 3856770 (1974-12-01), Greven
Nature, 258, pp. 577-579 (1975).
Nature, 260, p. 624 (1976).
Nature, 260, p. 625 (1976).

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