Methionine sulfone and S-substituted cysteine sulfone derivative

Details Methionine sulfone and S-substituted cysteine sulfone derivative Methionine sulfone and S-substituted cysteine sulfone derivative

1995-06-06

1997-07-08

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546245, 546205, 546206, 546210, 514326, A61K 31445, C07D29503

Patent

active

056461658

ABSTRACT:
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.

REFERENCES:
patent: 5439888 (1995-08-01), Shuman et al.
patent: 5484772 (1996-01-01), Sall et al.
patent: 5488037 (1996-01-01), Sall et al.
patent: 5498779 (1996-03-01), Neises et al.

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