Methionine sulfone and S-substituted cysteine sulfone derivative

Details Methionine sulfone and S-substituted cysteine sulfone derivative Methionine sulfone and S-substituted cysteine sulfone derivative

1995-06-06

1998-06-23

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544129, 544130, 544132, 544141, 546186, 546188, 546189, 546190, 546191, 546208, 546210, 5142362, 514326, 514316, A61K 31535, A61K 31445, C07D40112, C07D41312

Patent

active

057706000

ABSTRACT:
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.

REFERENCES:
patent: 5439888 (1995-08-01), Shuman et al.
patent: 5484772 (1996-01-01), Sall et al.
patent: 5488037 (1996-01-01), Sall et al.
patent: 5498779 (1996-03-01), Neises et al.

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