Methionine sulfone and S-substituted cysteine sulfone derivative

Details Methionine sulfone and S-substituted cysteine sulfone derivative Methionine sulfone and S-substituted cysteine sulfone derivative

1994-04-18

1998-07-07

Powers, Fiona T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

548110, 548253, 548537, 548953, 546205, 546226, 546245, 514 63, 514 18, 514330, 514381, 514423, A61K 31395, A61K 3140, C07D20709, C07D20504

Patent

active

057769273

ABSTRACT:
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.

REFERENCES:
patent: 5153176 (1992-10-01), Abe et al.
patent: 5252566 (1993-10-01), Shuman
patent: 5254546 (1993-10-01), Ardecky et al.
Carini, David J., et al., J. Med. Chem. 34:2525-2547 (1991).

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