Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-04-18
1997-08-19
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548253, 548491, 548537, 514381, 514423, A61K 3140, A61K 3141, C07D40312, C07D40314
Patent
active
056589395
ABSTRACT:
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.
REFERENCES:
patent: 5153176 (1992-10-01), Abe et al.
patent: 5254546 (1993-10-01), Ardecky et al.
Carini et al., "Nonpeptide Angiotensin II Receptor Antagonist: The Discovery of a Series of N-(Biphenylylmethyl)imidazoles as Potent, Orally Active Antihypertensives," J. Med. Chem. 34:2525-2547 (1991).
Abelman Matthew Mark
Ardecky Robert John
Nutt Ruth Foelsche
Corvas International Inc.
Richter Johann
Stockton Laura L.
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