Methionine sulfone and s-substituted cysteine sulfone derivative

Details Methionine sulfone and s-substituted cysteine sulfone derivative Methionine sulfone and s-substituted cysteine sulfone derivative

1994-04-28

1997-10-28

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548253, 548537, 514381, A61K 3140, C07D20706

Patent

active

056818440

ABSTRACT:
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.

REFERENCES:
patent: 5153176 (1992-10-01), Abe et al.
patent: 5254546 (1993-10-01), Ardecky et al.
Bajusz et al. Int. J. Peptide Protein Res. 12 (1978) 217-221. (8).
Carini et al., "Nonpeptide Angiotensin II Receptor Antagonists: The Discovery of a Series of N-(Biphenylylmethyl)imidazoles as Potent, Orally Active Antihypertensives," J. Med. Chem. 34:2525-2547 (1991).

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