Methionine aminopeptidase-2 inhibitors and methods of use...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S016700, C514S475000, C514S478000, C514S588000

Reexamination Certificate

active

07348307

ABSTRACT:
The present invention provides methods of treating a lymphoma (e.g., a T-cell lymphoma or a B-cell lymphoma) in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention, for example, compounds of formulae I and XV:

REFERENCES:
patent: 4703107 (1987-10-01), Monsigny et al.
patent: 5135919 (1992-08-01), Folkman et al.
patent: 5180735 (1993-01-01), Kishimoto et al.
patent: 5180738 (1993-01-01), Kishimoto et al.
patent: 5290807 (1994-03-01), Folkman et al.
patent: 5422363 (1995-06-01), Yanai et al.
patent: 5648382 (1997-07-01), Billington et al.
patent: 5698586 (1997-12-01), Kishimoto et al.
patent: 5767293 (1998-06-01), Oku et al.
patent: 5789405 (1998-08-01), Oku et al.
patent: 6017954 (2000-01-01), Folkman et al.
patent: 6086865 (2000-07-01), Folkman et al.
patent: 6584477 (2003-06-01), Mosher, Jr.
patent: 6584847 (2003-07-01), Hirose
patent: 6919307 (2005-07-01), Olson et al.
patent: 7037890 (2006-05-01), Olson et al.
patent: 7105482 (2006-09-01), Olson et al.
patent: 2002/0151493 (2002-10-01), Olson et al.
patent: 2002/0193298 (2002-12-01), Olson et al.
patent: 2005/0059585 (2005-03-01), Olson et al.
patent: 2005/0130903 (2005-06-01), Olson et al.
patent: 2006/0069028 (2006-03-01), Olson et al.
patent: 0354767 (1990-02-01), None
patent: 0357061 (1990-03-01), None
patent: 0359036 (1990-03-01), None
patent: 0387650 (1990-09-01), None
patent: 0415294 (1991-03-01), None
patent: WO-98/13059 (1998-04-01), None
patent: WO-98/56372 (1998-12-01), None
patent: WO-99/59986 (1999-11-01), None
patent: WO-99/61432 (1999-12-01), None
patent: WO-00/64486 (2000-11-01), None
patent: WO-00/69472 (2000-11-01), None
Denmeade SR, et al. “Enzymatic activation of a doxorubicin-peptide prodrug by prostate-specific antigen.”Cancer Res. Jun. 15, 1998;58(12):2537-40.
Griffith EC, et al. “Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2,”Proc. Natl. Acad. Sci. USA, vol. 95:15183-15188 (1998).
Griffith EC, et al. “Methionine aminopeptidase (type 2) is the common target for angiogensis inhibitors AGM-1470 and ovalicin”.Chem Biol. Jun. 1997;4(6):461-71.
Han CK, et al. “Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2.”Bioorg Med Chem Lett. Jan. 3, 2000;10(1):39-43.
Landquist, JK “Some Degradation Products of Fumagillin”J. Chem. Soc. 1956: 4237-4245.
Tarbell et al. “Chemical Evidence For At Least Two Different Precursors To Cyclohexene Formed By Electron Irradiation Of Cyclohexane.”Journal of the American Chemical Society, Feb. 20, 1960; 82:1005-1007.
Liu S, et al. Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science. Nov. 13, 1998;282(5392):1324-7.
Sin N, et al. “The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2.”Proc Natl Acad Sci U S A. Jun. 10, 1997;94(12):6099-103.
Timar F, et al. “The antiproliferative action of a melphalan hexapeptide with collagenase-cleavable site.”Cancer Chemother Pharmacol. 1998;41(4):292-8.
Turk BE, et al. “Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells.”Chem Biol. Nov. 1999;6(11):823-33.
De Marre, A. et al. “Synthesis and evaluation of macromolecular prodrugs of mitomycin C,”Journal of Controlled Release36(1/2):87-97 (1995).
Nichifor, M. et al. “Chemical and enzymatic hyrdolysis of dipeptide derivatives of 5-fluorouracil,”Journal of Controlled Release47:271-281 (1997).
Zhang, Peng, et al., “Angiogenesis Inhibitors Specific for Methionine Aminopeptidase 2 as Drugs for Malaria and Leishmaniasis,”Journal of Biomedical Science, vol. 9:34-40 (2002).
Tarbell et al, “The Structure of Fumagillin,”Journal of the American Chemical Society, vol. 82(4):1005-1007 (1960).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methionine aminopeptidase-2 inhibitors and methods of use... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methionine aminopeptidase-2 inhibitors and methods of use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methionine aminopeptidase-2 inhibitors and methods of use... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3971590

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.