Methionine aminopeptidase-2 inhibitors and methods of use...

Details Methionine aminopeptidase-2 inhibitors and methods of use... Methionine aminopeptidase-2 inhibitors and methods of use...

2006-09-12

2006-09-12

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S016700, C514S475000, C514S478000, C514S588000

Reexamination Certificate

active

07105482

ABSTRACT:
The present invention provides methods of treating, parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention.

REFERENCES:
patent: 4703107 (1987-10-01), Monsigny et al.
patent: 5135919 (1992-08-01), Folkman et al.
patent: 5180735 (1993-01-01), Kishimoto et al.
patent: 5180738 (1993-01-01), Kishimoto et al.
patent: 5290807 (1994-03-01), Folkman et al.
patent: 5422363 (1995-06-01), Yanai et al.
patent: 5648382 (1997-07-01), Billington et al.
patent: 5698586 (1997-12-01), Kishimoto et al.
patent: 5767293 (1998-06-01), Oku et al.
patent: 5789405 (1998-08-01), Oku et al.
patent: 6017954 (2000-01-01), Folkman et al.
patent: 6086865 (2000-07-01), Folkman et al.
patent: 6548477 (2003-04-01), Olson et al.
patent: 6919307 (2005-07-01), Olson et al.
patent: 2002/0193298 (2002-12-01), Olson et al.
patent: 0 354 767 (1990-02-01), None
patent: 0 357 061 (1990-03-01), None
patent: 0 359 036 (1990-03-01), None
patent: 0 387 650 (1990-09-01), None
patent: 0 415 294 (1991-03-01), None
patent: 0 415 294 (1991-03-01), None
patent: WO 98/13059 (1998-04-01), None
patent: WO 98/56372 (1998-12-01), None
patent: WO 9959986 (1999-11-01), None
patent: WO 9961432 (1999-12-01), None
patent: WO 00/64486 (2000-11-01), None
patent: WO 00/64486 (2000-11-01), None
patent: WO 0069472 (2000-11-01), None
Denmeade SR, et al. “Enzymatic activation of a doxorubicin-peptide prodrug by prostate-specific antigen.”Cancer Res. Jun. 15, 1998;58(12):2537-40.
Griffith EC, et al. “Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2.”Proc Natl Acad Sci U S A. Dec. 22, 1998;95(26):15183-8.
Griffith EC, et al. “Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin”.Chem Biol. Jun. 1997;4(6):461-71.
Han CK, et al. “Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2.”Bioorg Med Chem Lett. Jan 3, 2000;10(1):39-43.
Landquist, JK “Some Degradation Products of Fumagillin”J. Chem. Soc. 1956: 4237-4245.
Tarbell et al. “Chemical Evidence For At Least Two Different Precursors To Cyclohexene Formed By Electron Irradiation Of Cyclohexane” Feb. 20, 1960; 82:1005-1007.
Liu S, et al. Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science. Nov. 13, 1998;282(5392):1324-7.
Sin N, et al. “The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2.”Proc Natl Acad Sci U S A. Jun. 10, 1997;94(12):6099-103.
Timar F, et al. “The antiproliferative action of a melphalan hexapeptide with collagenase-cleavable site.”Cancer Chemother Pharmacol. 1998;41(4):292-8.
Turk BE, et al. “Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells.”Chem Biol. Nov. 1999;6(11):823-33.
De Marre, A. et al. “Synthesis and evaluation of macromolecular prodrugs of mitomycin C,”Journal of Controlled Release36(1/2):87-97 (Sep. 1995).
Nichifor, M. et al. “Chemical and enzymatic hyrdolysis of dipeptide derivatives of 5-fluorouracil,”Journal of Controlled Release47:271-281 (1997).

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