Methioninase formulations

Details Methioninase formulations Methioninase formulations

1997-08-19

1999-03-30

Lau, Kawai

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Transferases

424 942, 435188, 435232, A61K 3851, C12N 996, C12N 988

Patent

active

058885064

ABSTRACT:
Improved formulations of methioninase which contain methioninase in crystalline, lyophilized, or conjugated form are disclosed. The methioninase in these compositions has a specific activity of at least 20 U/mg and the formulations are detergent free and contain less than 1 ng endotoxin per mg protein.

REFERENCES:
Berezov, T.T. et al. "An improved procedure for isolation and purification of methionine gamma-lyase from Pseudomonase putida." Voprosy Meditsinskoi Khimii (1983), vol. 29, No. 4, pp. 131-135, 1983.

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