Methano carbacyclin analogs

Details Methano carbacyclin analogs Methano carbacyclin analogs

1980-12-22

1982-09-14

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

564 99, 564152, 560 45, 564158, 564171, 560 56, 564174, 564374, 562444, 564384, 564427, 562453, 564453, 564454, 562466, 424244, 42424854, 562499, 424250, 424263, 260239BF, 424267, 424274, 260464, 424275, 424285, 260465D, 424305, 424308, 542429, 424317, 424318, 549 66, 424320, 424321, 549 78, 424324, 424325, 549 79, 424330, 424331, 568633, 424339, 424340, 568808, 424343, 548540, 568817, 549305, 549465, 544155, 549496, 549499, 544380, 549501, 549502, 546203, 546204, 546283, 546284, 546285, 564 80, 564 88, 564

Patent

active

043496890

ABSTRACT:
The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.

REFERENCES:
patent: 4238414 (1980-12-01), Morton

Affiliated with

Also associated with

Rating

Methano carbacyclin analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methano carbacyclin analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methano carbacyclin analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2155887