Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-10-09
1997-10-28
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514307, 514320, 514337, 514338, 514414, 544376, 546148, 546196, 5462541, 548454, C07D40506, A61K 31495
Patent
active
056818360
ABSTRACT:
The methanesulfonate salt of a class of antipsychotic compounds comprising antagonists of dopamine receptor subtypes within the brain, being extremely potent antagonists of the human dopamine D.sub.4 receptor subtype and having a selective affinity for the D.sub.4 subtype over other dopamine receptor subtypes, possess advantageous qualities in terms of their improved aqueous solubility relative to the corresponding free base and, as such, provide for greater ease of formulation and display enhanced pharmacokinetic properties, including oral absorption.
REFERENCES:
Zagurerskii, et al., Chemical Abstracts, vol. 120, No. 11, ABS. No. 124908t, (1994), "Derivatives of 2-aryl-3-(3-amioethylbenzofuran with neurotropic activity".
Chemical Abstracts, vol. 93, No. 7, ABS. No. 71429c, (1980), Prewysz-Kowinto A., et al., "Synthesis of 3-aminomethyl derivatives of 2-carbethoxy benzofuran".
Curtis Neil Roy
Kulagowski Janusz Jozef
Leeson Paul David
Dentz Bernard
Merck Sharp & Dohme Ltd.
North Robert J.
Winokur Melvin
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