Methanediphosphonate derivative, its manufacturing process and i

Details Methanediphosphonate derivative, its manufacturing process and i Methanediphosphonate derivative, its manufacturing process and i

1994-11-17

1996-06-18

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

556405, 558161, 562 13, C07F 940, C07F 938

Patent

active

055279406

ABSTRACT:
The present invention relates to a methanediphosphonate derivative, its manufacturing process and pharmaceutical applications, that is represented with the following formula: ##STR1## (wherein, B is either hydrogen, an alkyl group, hydroxyl group, alkoxy group or amino group, D is either sulfur, oxygen, NH, alkyl-substituted N, CH.sub.2 or SCH.sub.2, X represents an alkyl group, alkyl group having a hetero atom as a substitution group, an aryl group or an acyl group, m represents an integer of 1 to 5, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, alkyl groups having 1 to 7 carbon atoms or pharmaceutically allowable cations). The compound of the present invention has excellent IL-1 inhibitory action, antioxidation action and bone resorption inhibitory action, and is useful as an antiinflammatory agent, antirheumatic, bone metabolic disease drug, autoimmune disease drug, osteoporosis drug and so forth.

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