Methane-sulfonamide derivatives, the preparation thereof and com

Details Methane-sulfonamide derivatives, the preparation thereof and com Methane-sulfonamide derivatives, the preparation thereof and com

1978-06-05

1979-10-30

Rush, Raymond V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548217, 548241, A61K 3142, C07D26120, C07D26356

Patent

active

041728963

ABSTRACT:
Methane-sulfonamide derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen or a halogen atom, R.sub.2 and R.sub.3 are the same or different and are each hydrogen or a straight or branched alkyl having 1 to 3 carbon atoms, and one of X and Y is a carbon atom and another is a nitrogen atom, provided that the group: --CH.sub.2 SO.sub.2 NR.sub.2 R.sub.3 is bonded to the carbon atom of either of X and Y,
and an alkali metal salt thereof, and a process for the preparation of said methane-sulfonamide derivatives. Said compounds have an excellent anticonvulsant activity and are useful as anticonvulsants for controlling convulsions and seizures in patients with epilepsy.

REFERENCES:
patent: 3833608 (1974-09-01), Rooney et al.
Noller--"Chemistry of Organic Compounds"--W. B. Saunders Company--(1965), pp. 314-315.

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