METH1 polynucleotides

Details METH1 polynucleotides METH1 polynucleotides

2007-05-22

2007-05-22

Canella, Karen A. (Department: 1643)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252300, C435S254110, C435S320100, C435S325000, C435S455000, C435S471000, C536S023500, C536S024310

Reexamination Certificate

active

09373658

ABSTRACT:
The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.

REFERENCES:
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5639725 (1997-06-01), O'Reilly et al
patent: 5837680 (1998-11-01), Moses et al.
patent: 6416974 (2002-07-01), Holtzman et al.
patent: 6649377 (2003-11-01), Allard et al.
patent: 766767 (1999-08-01), None
patent: 36226/00 (2000-09-01), None
patent: 0 742 012 (1996-11-01), None
patent: 0 874 050 (1998-10-01), None
patent: WO-93/16716 (1993-09-01), None
patent: WO 98/55643 (1998-12-01), None
patent: WO-98/56804 (1998-12-01), None
patent: WO 99/07850 (1999-02-01), None
patent: WO-99/14234 (1999-03-01), None
patent: 1 004 674 (2000-05-01), None
Burgess et al “Possible Dissociation of the Heparin-binding and Mitogenic Acivities of Heparin-binding Growth Factor-1 from Its Receptor-binding Activities by Site-directed Mutagenesis of a single Lysine Residue”, Journal of Cellular Biology, vol. 111, pp., 1990.
Lazar et al, “Transforming Growth Factor Alpha: Mutation of Aspartic Acid 47 and Leuine 48 Results in Different Biological Activities”, Molecular and Cellular Biology, vol. 8, pp. 1247-1252, 1988.
Verma et al (Nature, 1997, vol. 389, pp. 239-242).
Eck et al (Gene-Based Therapy, In: The Pharmacological Basis of Therapeutics, Goodman and Gilman, Ed.s, 1996, pp. 77-10.
Orkin et al (“Report and Recommendation of the Panel to Assess the NIH Investment in Research on Gene Therapy”, NIH, 1995).
The abstract of Trikha et al, Cancer Research, 1994, vol. 54, pp. 4993-4998.
U.S. Appl. No. 60/058,108.
U.S. Appl. No. 60/054,966.
Adams, J.C., “Molecules in Focus: Thrombospondin-1,”Int. J. Biochem. Cell Biol. 29:861-865 (Jun. 1997).
Asch, A.S. et al., “Analysis of CD36 Binding Domains: Ligand Specificity Controlled by Dephosphorylation of an Ectodomain,”Science 262:1436-1440 (1993).
Bjarnason, J.B. and J.W. Fox, “Snake Venom Metalloendopeptidases: Reprolysins,”Meth. Enzymol. 248:345-369 (1995).
Bornstein, P., “Thrombospondins: structure and regulation of expression,”FASEB J. 6:3290-3299 (1992).
Catimel, B. et al., “Human platelet glycoprotein IIIb binds to thrombospondin fragments bearing theC-terminal region, and/or the type I repeats (CSVTCG motif), but not theN-terminal heparin-binding region,”Biochem. J. 284:231-236 (1992).
Colige, A. et al., “cDNA cloning and expression of bovine procollagen I N-proteinase: A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components,”Proc. Natl. Acad. Sci. USA 94:2374-2379 (Mar. 1997).
Dameron, K.M. et al., “Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1,”Science 265:1582-1584 (1994).
Dawson, D.W. et al., “CD36 Mediates the In-Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells,”J. Cell Biol. 138:707-717 (Aug. 1997).
Guo, N.-H. et al., “Heparin-binding Peptides from the Type I Repeats of Thrombospondin,”J. Biol. Chem. 267:19349-19355 (1992).
Guo, N.-H. et al., “Antiproliferative and antitumor activities of D-reverse peptides derived from the second type-1 repeat of thrombospondin-1,”J. Peptide Res. 50:210-221 (Sep. 1997).
Iruela-Arispe, M.L. et al., “Differential Expression of Thrombospondin 1, 2, and 3 During Murine Development,”Develop. Dynamics 197:40-56 (1993).
Iruela-Arispe, M.L. and H.F. Dvorak, “Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors,”Thrombosis&Haemostasis 78:672-677 (Jul. 1997).
Kuno, K. et al., “Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene,”J. Biol. Chem. 272:556-562 (Jan. 1997).
Kyriakides, T.R. et al., “Mice That Lack Thrombospondin 2 Display Connective Tissue Abnormalities That Are Associated with Disordered Collagen Fibrillogenesis, an Increased Vascular Density, and a Bleeding Diathesis,”J. Cell Biol. 140:419-430 (Jan. 1998).
Lawler, J. et al., “Thrombospondin-1 Is Required for Normal Murine Pulmonary Homeostasis and Its Absence Causes Pneumonia,”J. Clin. Invest. 101:982-992 (Mar. 1998).
Nishimori, H. et al., “A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis,”Oncogene 15:2145-2150 (Oct. 1997).
Pfaff, M. et al., “Comparison of Disintegrins with Limited Variation in the RGD Loop in Their Binding to Purified Integrins αIIbβ3, αVβ3 and α5β1 and in Cell Adhesion Inhibition,”Cell Adhesion&Comm. 2:491-501 (1994).
Rawlings, N.D, and A.J. Barrett, “Evolutionary Families of Metallopeptidases,”Meth. Enzymol. 248:183-229 (1995).
Tolsma, S.S. et al., “Peptides Derived from Two Seperate Domains of the Matrix Protein Thrombospondin-1 Have Anti-Angiogenic Activity,”J. Cell Biol. 122:497-511 (1993).
Usami, Y. et al., “A 28 kDa-protein with disintegrin-like structure (jarahagin-C) purified fromBothrops jararacavenom inhibits collagen- and ADP-induced platelet aggregation,”Biochem.&Biophys. Res. Comm. 201:331-339 (1994).
Vogel, T. et al., “Modulation of Endothelial Cell Proliferation, Adhesion, and Motility by Recombinant Heparin-Binding Domain and Synthetic Peptides From the Type I Repeats of Thrombospondin,”J. Cell. Biochem. 53:74-84 (1993).
Wolfsberg, T.G. and J.M. White, “Review: ADAMs in Fertilization and Development,”Develop. Biol. 180:389-401 (1996).
GenBank Accession No. D67076, Kuno, K. (Feb. 1999).
GenBank Accession No. AB001735, Kuno, K. (Jan. 1998).
GenBank Accession No. X14787, Hennessy, S.W. et al. (1995).
GenBank Accession No. U64857, Wilson, R. et al. (Nov. 1998).
GenBank Accession No. X04665, Lawler, J. and R.O. Hynes (1995).
GenBank Accession No. M64866, Bornstein, P. et al. (1993).
GenBank Accession No. L07803, Laherty, C.D. et al. (1994).
GenBank Accession No. U08006, Michelotti, G.A. et al. (1995).
GenBank Accession No. M16974, Rao, A.G. et al. (1994).
GenBank Accession No. L13855, Dean, H.J. and A.K. Cheung (1994).
GenBank Accession No. AL021529, Murphy, L. and D. Harris (Jan. 1998).
GenBank Accession No. D86074, Sudo, S. (Feb. 1999).
GenBank Accession No. L05390, Blanco, G. et al. (1993).
GenBank Accession No. Z69361, Gajadsty, S. et al. (Nov. 1998).
GenBank Accession No. X99599, Borghese, R. et al. (Feb. 1998).
GenBank Accession No. AF018073, Schneider, K.H. et al. (Oct. 1997).
GenBank Accession No. L23760, Lin, Q. et al. (1994).
GenBank Accession No. Z46970, Wiese, M. (1995).
GenBank Accession No. AC004449, Lamerdin, J.E. et al. (Sep. 1998).
GenBank Accession No. Z69589, Dreusch, A. et al. (1996).
GenBank Accession No. Z22279, Zabarovsky, E. et al. (1994).
GenBank Accession No. X17524, Ohama, T. et al. (1992).
GenBank Accession No. AB005287, Ueno, A. et al. (Mar. 1998).
GenBank Accession No. X87619, Zafar, R.S. (1995).
GenBank Accession No. M87276, Laherty, C.D. et al. (1994).
GenBank Accession No. M62458, Lawler, J. et al. (1994).
GenBank Accession No. AB002364, Nagase, T. et al. (Feb. 1999).
GenBank Accession No. AB005297, Nakamura, Y. et al. (Nov. 1997).
GenBank Accession No. X69161, Akam, M.E. et al. (1995).
GenBank Accession No. X16619, Debuchy, R. et al. (Feb. 1999).
GenBank Accession No. I36448, Goodearl, A. et al. (Mar. 1997).
GenBank Accession No. L12260, Marchionni, M.A. et al. (Sep

Affiliated with

Also associated with

Rating

METH1 polynucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with METH1 polynucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and METH1 polynucleotides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3730589