(Meth)acryloyloxy substituted acetylsalicylates and polymers the

Details (Meth)acryloyloxy substituted acetylsalicylates and polymers the (Meth)acryloyloxy substituted acetylsalicylates and polymers the

1996-03-12

1997-12-02

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 7831, 424 7808, 5263285, 526304, 526306, 526318, 526320, 526321, 526326, 526328, 560 41, 560 76, 562433, 562496, 564155, 564159, C08F 2058, C08F 2018, C08K 501, C07C22900

Patent

active

056933207

ABSTRACT:
Novel acetylsalicylic acid derivatives having general formula (I) are provided, in which R.sup.1 is hydrogen or methyl; R.sup.2 is --O-- or --NH--; and W is hydroxy, halogen, lower alkoxy, lower alkenyloxy, lower alkynyloxy, cycloalkyloxy, aryloxy, aralkyloxy, acyloxy, or --N(R.sup.3)(R.sup.4) wherein the lower alkoxy, the lower alkenyloxy, the lower alkynyloxy, the cycloalkyloxy, the aryloxy, the aralkyloxy, and the acyloxy are optionally substituted with hydroxy, carboxyl, lower alkoxy, lower alkyl, halogen, nitro, and amino. The invention also pertains to a polymer made from such derivatives and a medical equipment containing the polymer. The polymer is useful in the prevention of platelet aggregation thereon. ##STR1##

REFERENCES:
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patent: 4500601 (1985-02-01), Whitcomb
patent: 5026860 (1991-06-01), Buchan et al.
patent: 5385997 (1995-01-01), Buchan et al.
patent: 5422395 (1995-06-01), Ooura et al.
Chemical Abstracts--"Synthetic High Polymers"--vol. 86, No. 8, Feb. 21, 1977.
Chemical Abstract--"Chemistry of Synthetic High Polymers" vol. 115, No. 10, Sep. 9, 1991.
"Synthesis and Microstructure of Polymers from o-Methacryloyloxybenzoic Acids"--J. San Roman et al., Journal of Polymer Science, Part A, Polymer Chemistry, vol. 25, pp. 203-214 (1987).
J. San Roman et al. "Application of new coatings for vascular grafts based on polyacrylic systems with antiaggregating activity"--Biomaterials--vol. 15, No. 10, pp. 759-765--1994.

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