Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1998-04-28
2000-08-08
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564233, A61K 31155
Patent
active
06100300&
ABSTRACT:
Novel metformin formulations are provided which include metformin or metformin salts preferably the hydrochloride salt in doses below that employed for treating diabetes such as metformin in daily amounts of 400 mg or below. A method for treating peripheral vascular disease including intermittent claudication employing such metformin formulations is also provided.
REFERENCES:
Rouru et al. Life Sciences 1992, 50(23), 1813-1820.
Montanari, G., et al, "Treatment with Low Dose Metformin in Patients with Peripheral Vascular Disease", Pharmacological Research, vol. 25, No. 1, 1992, pp. 63-73.
Sirtori, C.R., et al, "Metformin Improves Peripheral Vascular Flow in Nonhyperlipidemic Patients with Arterial Disease", J. of Cardiovascular Pharmacology, vol. 6, No. 5, 1984, pp. 914-923.
Bristol--Myers Squibb Company
Fonda Kathleen K.
Rodney Burton
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