Meterodimeric T lymphocyte receptor antibody

Details Meterodimeric T lymphocyte receptor antibody Meterodimeric T lymphocyte receptor antibody

1988-11-14

1993-02-23

Richter, Johann

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

53038822, 53038875, A61K 3514

Patent

active

051891476

ABSTRACT:
Disclosed is a heterodimeric T lymphocyte receptor comprising an alpha and a beta subunit. Each subunit consists of a signal peptide, variable, joining, constant, transmembrane, and cytoplasmic regions. The two subunits are connected by a disulfide bond between cysteine residues located between the constant and transmembrane region.
The structure, amino acid, and nucleotide sequence of the lymphocyte receptor were determined using cDNA cones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed

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