Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition
Patent
1992-11-05
1995-02-21
Warden, Robert J.
Chemical apparatus and process disinfecting, deodorizing, preser
Control element responsive to a sensed operating condition
422100, 137885, 13762512, 13762515, 251 611, G01N 100
Patent
active
053913531
DESCRIPTION:
BRIEF SUMMARY
In laboratory technology one frequently encounters the problem that certain substances in the form of gases or liquids must be metered, i.e. a given quantity of said substance must be dispensed. Particularly in the analytical field, for instance upon the carrying out of tests, different reagents must be introduced into reaction vessels one after the other. Since reagents must very frequently be introduced in identical quantity into a large number of reaction vessels, an automated sample dispenser or multi-distributor is advantageous.
Upon the analytical separation of mixtures, the eluate coming for instance from a separating column is separated into individual fractions by means of fraction collectors.
These fields of use require a metering device which operates automatically and reliably.
It is the object of the present invention to make available a metering device which has a plurality of control valves, it being possible to control each valve independently of the other valves. There is to be made available, in particular, a metering device, which is suitable for use in a sequenator for the analysis of proteins and peptides.
The object of the present invention is a metering device which is free of dead volume and which has a plurality of pneumatically controllable valves and is characterized by the fact that the valves are arranged substantially in a circle on an annular support.
In one preferred embodiment, the annular support encloses an essentially circular hollow space.
Particularly upon the use as metering device in a sequenator or in a synthesis machine for the production of nucleotides or peptides, this geometric arrangement affords the advantage that one or more reaction vessels can be arranged in the circular hollow space. The individual feed lines from the control valves to the reaction vessels can be kept very short due to the radial arrangement.
In the case of a sequenator, the reactor and the converter can be located within the circular hollow space. For an explanation of the problems which occur upon the automatic sequencing of proteins and peptides which are present in only very small quantities, reference is had to the general article by B. Wittmann-Liebold "Advanced automatic microsequencing of proteins and peptides, Modern Methods in Protein Chemistry"--Review Articles, (1983), Walter de Gryter & Co., Berlin, N. Y.
In one preferred embodiment, the metering device of the invention consists of a first ring which has screw connections and assures mechanical stability. This first ring can consist of several individual structural parts. Thus, for instance, the first ring can consist of an upper and a lower ring which are connected via an intermediate ring by means of fasteners. This first ring assures the mechanical stability of the metering device and is therefore preferably made of metal. Particularly preferred materials are stainless high-grade steel and aluminum.
Furthermore, the metering device of the invention has a second ring which is made of a chemically inert material. There enter into consideration for this quartz or a copolymer known as KelF made from vinylidene fluoride and chlortrifluorethylene. Other synthetic materials also enter into consideration, provided they have the required mechanical strength and the required resistance to the chemical reagents with which the material can come into contact. The selection of the most suitable material of course always depends on the reagents with which the metering device of the invention comes into contact. Between the first and the second ring there is arranged a diaphragm consisting of a chemically inert material.
The first ring will, as a rule, be constructed in such a manner that the second ring is held by it, the second ring being pressed against the upper part of the first ring.
In the case of the metering device according to the invention, a pneumatically controllable valve is formed in the manner that the first ring has a hole in its upper part which hole extends perpendicularly to the diameter of the ring from the surface of
REFERENCES:
patent: 3202180 (1963-02-01), Gray
patent: 3782682 (1974-01-01), Lale
patent: 4633904 (1987-01-01), Schumann et al.
patent: 4702889 (1987-10-01), Cabrera et al.
patent: 4722830 (1988-02-01), Urie et al.
Tran Hien
Warden Robert J.
WITA GmbH, Technologiezentrum Teltow
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