Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-10-09
2007-10-09
Martinell, James (Department: 1634)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S325000, C435S320100, C435S252300, C536S023500, C536S023100
Reexamination Certificate
active
10601091
ABSTRACT:
Gene sequences as shown in SEQ ID NO:1-18 have been discovered and isolated, and found to be significantly associated with metastatic spread of breast and colon cancer cells to other organs. Methods are provided for determining the risk of metastasis of a breast or colon tumor, which involve determining whether a tissue sample from a tumor expresses a polypeptide encoded by a gene as shown in SEQ ID NOS:1-18, or a substantial portion thereof. One of the gene sequences encodes a novel aspartyl protease termed CSP56, which can be used to provide reagents and methods for determining which tumors are likely to metastasize and for suppressing metastases of these tumors. Clinicians can use this information to predict which tumors will metastasize to other organs and to provide relevant therapies to appropriate patients.
REFERENCES:
patent: 5514558 (1996-05-01), Ceriani et al.
patent: 5658784 (1997-08-01), Eckner et al.
patent: 5994104 (1999-11-01), Anderson et al.
patent: 6025180 (2000-02-01), Powell et al.
patent: 0786519 (1997-07-01), None
patent: 0848062 (1998-06-01), None
patent: WO-91/04328 (1991-04-01), None
patent: WO-96/01320 (1996-01-01), None
patent: WO-96/30511 (1996-10-01), None
patent: WO-96/40769 (1996-12-01), None
patent: WO-98/39448 (1998-09-01), None
patent: WO-99/33963 (1999-07-01), None
patent: WO-00/17369 (2000-03-01), None
Hillier et al, GenBank® Accession No. AA056282 (Nov. 29, 1996).
Bonaldo et al., Genome Res., 6(9):791, 1996.
Hillier et al., Genome Res., 6(9):807, 1996.
Adams et al., NATURE 377 (SUPP), 3, Abstract Only, 1995.
Wallace et al., Methods Enzymol., 152:432, 1987.
DUFFY,Proteases as Prognostic Markers in Cancer, Clinical Cancer Research, 2:613-618, 1996.
Chen et al.,Membrane Proteases as Potential Diagnostic and Therapeutic Targets for Breast Malignancy, Breast Cancer Research And Treatment, 31:217-226, 1994.
Hillier, L., et al., “zb44h05.r1”, accession No. W20360, Database SRS [online] EBI; May 5, 1996 (abstract).
Duffy, M.J. “Proteases as prognostic markers in cancer”, Clinical Cancer Research, Apr. 1996, vol. 2, pp. 613-618.
Chen, W., et al., “Membrane proteases as potential diagnostic and therapeutic targets for breast malignancy”, Breast Cancer Research and Treatment; 1994, 31, pp. 217-226.
Adams, M. D., et al., “Use of human BAC End sequences for Sequence-Ready Map Building”, accession No. AQ198349, Database SRS [online] EBI; Sep. 23, 1998 (abstract).
Giese Klaus
Xin Hong
Alexander Lisa E.
Attwell Gwilym
Chiron Corporation
Harbin Alisa A.
Martinell James
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